ALSUntangled 59: Tamoxifen.
Publication
, Journal Article
Bedlack, R; Kihuwa-Mani, S; Barkhaus, PE; Bereman, M; Caress, JB; Crayle, J; Pattee, GL; Heiman Patterson, T; Wicks, P; Zach, N; Carter, GT; Salmon, K
Published in: Amyotroph Lateral Scler Frontotemporal Degener
November 2021
Here we use the ALSUntangled methodology to review Tamoxifen as an ALS treatment. We show that it has plausible mechanisms, a positive preclinical study, a case report and 2 small trials suggesting benefits. We show that it appears reasonably safe, though there is a small risk of developing cancer with long term use. While we cannot yet endorse this as an ALS treatment, there is enough evidence to warrant another larger ALS trial.
Duke Scholars
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Published In
Amyotroph Lateral Scler Frontotemporal Degener
DOI
EISSN
2167-9223
Publication Date
November 2021
Volume
22
Issue
7-8
Start / End Page
595 / 598
Location
England
Related Subject Headings
- Tamoxifen
- Humans
- Amyotrophic Lateral Sclerosis
- 3209 Neurosciences
- 1109 Neurosciences
- 1103 Clinical Sciences
Citation
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Chicago
ICMJE
MLA
NLM
Bedlack, R., Kihuwa-Mani, S., Barkhaus, P. E., Bereman, M., Caress, J. B., Crayle, J., … Salmon, K. (2021). ALSUntangled 59: Tamoxifen. Amyotroph Lateral Scler Frontotemporal Degener, 22(7–8), 595–598. https://doi.org/10.1080/21678421.2021.1876731
Bedlack, Richard, Sky Kihuwa-Mani, Paul E. Barkhaus, Michael Bereman, James B. Caress, Jesse Crayle, Gary L. Pattee, et al. “ALSUntangled 59: Tamoxifen.” Amyotroph Lateral Scler Frontotemporal Degener 22, no. 7–8 (November 2021): 595–98. https://doi.org/10.1080/21678421.2021.1876731.
Bedlack R, Kihuwa-Mani S, Barkhaus PE, Bereman M, Caress JB, Crayle J, et al. ALSUntangled 59: Tamoxifen. Amyotroph Lateral Scler Frontotemporal Degener. 2021 Nov;22(7–8):595–8.
Bedlack, Richard, et al. “ALSUntangled 59: Tamoxifen.” Amyotroph Lateral Scler Frontotemporal Degener, vol. 22, no. 7–8, Nov. 2021, pp. 595–98. Pubmed, doi:10.1080/21678421.2021.1876731.
Bedlack R, Kihuwa-Mani S, Barkhaus PE, Bereman M, Caress JB, Crayle J, Pattee GL, Heiman Patterson T, Wicks P, Zach N, Carter GT, Salmon K. ALSUntangled 59: Tamoxifen. Amyotroph Lateral Scler Frontotemporal Degener. 2021 Nov;22(7–8):595–598.
Published In
Amyotroph Lateral Scler Frontotemporal Degener
DOI
EISSN
2167-9223
Publication Date
November 2021
Volume
22
Issue
7-8
Start / End Page
595 / 598
Location
England
Related Subject Headings
- Tamoxifen
- Humans
- Amyotrophic Lateral Sclerosis
- 3209 Neurosciences
- 1109 Neurosciences
- 1103 Clinical Sciences