Skip to main content

ALSUntangled 59: Tamoxifen.

Publication ,  Journal Article
Bedlack, R; Kihuwa-Mani, S; Barkhaus, PE; Bereman, M; Caress, JB; Crayle, J; Pattee, GL; Heiman Patterson, T; Wicks, P; Zach, N; Carter, GT; Salmon, K
Published in: Amyotroph Lateral Scler Frontotemporal Degener
November 2021

Here we use the ALSUntangled methodology to review Tamoxifen as an ALS treatment. We show that it has plausible mechanisms, a positive preclinical study, a case report and 2 small trials suggesting benefits. We show that it appears reasonably safe, though there is a small risk of developing cancer with long term use. While we cannot yet endorse this as an ALS treatment, there is enough evidence to warrant another larger ALS trial.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Amyotroph Lateral Scler Frontotemporal Degener

DOI

EISSN

2167-9223

Publication Date

November 2021

Volume

22

Issue

7-8

Start / End Page

595 / 598

Location

England

Related Subject Headings

  • Tamoxifen
  • Humans
  • Amyotrophic Lateral Sclerosis
  • 3209 Neurosciences
  • 1109 Neurosciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bedlack, R., Kihuwa-Mani, S., Barkhaus, P. E., Bereman, M., Caress, J. B., Crayle, J., … Salmon, K. (2021). ALSUntangled 59: Tamoxifen. Amyotroph Lateral Scler Frontotemporal Degener, 22(7–8), 595–598. https://doi.org/10.1080/21678421.2021.1876731
Bedlack, Richard, Sky Kihuwa-Mani, Paul E. Barkhaus, Michael Bereman, James B. Caress, Jesse Crayle, Gary L. Pattee, et al. “ALSUntangled 59: Tamoxifen.Amyotroph Lateral Scler Frontotemporal Degener 22, no. 7–8 (November 2021): 595–98. https://doi.org/10.1080/21678421.2021.1876731.
Bedlack R, Kihuwa-Mani S, Barkhaus PE, Bereman M, Caress JB, Crayle J, et al. ALSUntangled 59: Tamoxifen. Amyotroph Lateral Scler Frontotemporal Degener. 2021 Nov;22(7–8):595–8.
Bedlack, Richard, et al. “ALSUntangled 59: Tamoxifen.Amyotroph Lateral Scler Frontotemporal Degener, vol. 22, no. 7–8, Nov. 2021, pp. 595–98. Pubmed, doi:10.1080/21678421.2021.1876731.
Bedlack R, Kihuwa-Mani S, Barkhaus PE, Bereman M, Caress JB, Crayle J, Pattee GL, Heiman Patterson T, Wicks P, Zach N, Carter GT, Salmon K. ALSUntangled 59: Tamoxifen. Amyotroph Lateral Scler Frontotemporal Degener. 2021 Nov;22(7–8):595–598.

Published In

Amyotroph Lateral Scler Frontotemporal Degener

DOI

EISSN

2167-9223

Publication Date

November 2021

Volume

22

Issue

7-8

Start / End Page

595 / 598

Location

England

Related Subject Headings

  • Tamoxifen
  • Humans
  • Amyotrophic Lateral Sclerosis
  • 3209 Neurosciences
  • 1109 Neurosciences
  • 1103 Clinical Sciences