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Concomitant control of mechanical properties and degradation in resorbable elastomer-like materials using stereochemistry and stoichiometry for soft tissue engineering.

Publication ,  Journal Article
Wandel, MB; Bell, CA; Yu, J; Arno, MC; Dreger, NZ; Hsu, Y-H; Pitto-Barry, A; Worch, JC; Dove, AP; Becker, ML
Published in: Nature communications
January 2021

Complex biological tissues are highly viscoelastic and dynamic. Efforts to repair or replace cartilage, tendon, muscle, and vasculature using materials that facilitate repair and regeneration have been ongoing for decades. However, materials that possess the mechanical, chemical, and resorption characteristics necessary to recapitulate these tissues have been difficult to mimic using synthetic resorbable biomaterials. Herein, we report a series of resorbable elastomer-like materials that are compositionally identical and possess varying ratios of cis:trans double bonds in the backbone. These features afford concomitant control over the mechanical and surface eroding degradation properties of these materials. We show the materials can be functionalized post-polymerization with bioactive species and enhance cell adhesion. Furthermore, an in vivo rat model demonstrates that degradation and resorption are dependent on succinate stoichiometry in the elastomers and the results show limited inflammation highlighting their potential for use in soft tissue regeneration and drug delivery.

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Published In

Nature communications

DOI

EISSN

2041-1723

ISSN

2041-1723

Publication Date

January 2021

Volume

12

Issue

1

Start / End Page

446

Related Subject Headings

  • Tissue Scaffolds
  • Tissue Engineering
  • Tensile Strength
  • Surface Properties
  • Stereoisomerism
  • Rats
  • Polymerization
  • Mice
  • Mesenchymal Stem Cells
  • Materials Testing
 

Citation

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ICMJE
MLA
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Wandel, M. B., Bell, C. A., Yu, J., Arno, M. C., Dreger, N. Z., Hsu, Y.-H., … Becker, M. L. (2021). Concomitant control of mechanical properties and degradation in resorbable elastomer-like materials using stereochemistry and stoichiometry for soft tissue engineering. Nature Communications, 12(1), 446. https://doi.org/10.1038/s41467-020-20610-5
Wandel, Mary Beth, Craig A. Bell, Jiayi Yu, Maria C. Arno, Nathan Z. Dreger, Yen-Hao Hsu, Anaïs Pitto-Barry, Joshua C. Worch, Andrew P. Dove, and Matthew L. Becker. “Concomitant control of mechanical properties and degradation in resorbable elastomer-like materials using stereochemistry and stoichiometry for soft tissue engineering.Nature Communications 12, no. 1 (January 2021): 446. https://doi.org/10.1038/s41467-020-20610-5.
Wandel, Mary Beth, et al. “Concomitant control of mechanical properties and degradation in resorbable elastomer-like materials using stereochemistry and stoichiometry for soft tissue engineering.Nature Communications, vol. 12, no. 1, Jan. 2021, p. 446. Epmc, doi:10.1038/s41467-020-20610-5.
Wandel MB, Bell CA, Yu J, Arno MC, Dreger NZ, Hsu Y-H, Pitto-Barry A, Worch JC, Dove AP, Becker ML. Concomitant control of mechanical properties and degradation in resorbable elastomer-like materials using stereochemistry and stoichiometry for soft tissue engineering. Nature communications. 2021 Jan;12(1):446.

Published In

Nature communications

DOI

EISSN

2041-1723

ISSN

2041-1723

Publication Date

January 2021

Volume

12

Issue

1

Start / End Page

446

Related Subject Headings

  • Tissue Scaffolds
  • Tissue Engineering
  • Tensile Strength
  • Surface Properties
  • Stereoisomerism
  • Rats
  • Polymerization
  • Mice
  • Mesenchymal Stem Cells
  • Materials Testing