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Quantitative whole-body magnetic resonance imaging in children with Pompe disease: Clinical tools to evaluate severity of muscle disease.

Publication ,  Journal Article
Fernandes, SA; Khan, AA; Boggs, T; Bowling, M; Austin, S; Stefanescu, M; Case, L; Kishnani, PS
Published in: JIMD Rep
January 2021

OBJECTIVE: Since the introduction of enzyme replacement therapy (ERT) with alglucosidase alfa, there has been increased survival in patients with Pompe disease. It is essential to characterize and quantify the burden of disease in these patients. Here, we report a measure of muscle fat infiltration in children with infantile and pediatric late-onset Pompe disease (IPD and LOPD, respectively) to better understand the extent of muscle involvement. METHODS: Eleven pediatric patients with Pompe disease (five IPD, six LOPD), ages 7-17 years, received whole-body magnetic resonance imaging (WBMRI), muscle strength testing using the modified Medical Research Council (mMRC) scale, functional assessment using gait, stairs, gowers, chair (GSGC), and urine glucose tetrasaccharide (Glc4) testing. The intramuscular fat seen on WBMRI was quantified using proton density fat fraction (PDFF) and correlated to appropriate muscle strength and functional tests, and urine Glc4. RESULTS: Patients with IPD, although younger, had higher mean PDFF values than LOPD patients (11.61% vs 8.52%). Significant correlation existed between PDFF and the GSGC assessment (r = .9273, P = .0003). Moderate correlation existed between PDFF and mMRC (r = -.667, P = .0831), and PDFF and urine Glc4 (r = .6121, P = .0667). Anterior tibialis was in the top quartile of muscle involvement for patients with LOPD. CONCLUSION: In the past, physical therapy assessments alone have been used to track disease progression. Here, we show the clinical utility of WBMRI in quantifying muscle involvement in children with Pompe disease, especially regarding the novel involvement of anterior tibialis in children with LOPD, to better assess baseline muscle burden and mapping disease progression in children treated with ERT.

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Published In

JIMD Rep

DOI

ISSN

2192-8304

Publication Date

January 2021

Volume

57

Issue

1

Start / End Page

94 / 101

Location

United States

Related Subject Headings

  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Fernandes, S. A., Khan, A. A., Boggs, T., Bowling, M., Austin, S., Stefanescu, M., … Kishnani, P. S. (2021). Quantitative whole-body magnetic resonance imaging in children with Pompe disease: Clinical tools to evaluate severity of muscle disease. JIMD Rep, 57(1), 94–101. https://doi.org/10.1002/jmd2.12174
Fernandes, Samuela A., Aleena A. Khan, Tracy Boggs, Michael Bowling, Stephanie Austin, Mihaela Stefanescu, Laura Case, and Priya S. Kishnani. “Quantitative whole-body magnetic resonance imaging in children with Pompe disease: Clinical tools to evaluate severity of muscle disease.JIMD Rep 57, no. 1 (January 2021): 94–101. https://doi.org/10.1002/jmd2.12174.
Fernandes SA, Khan AA, Boggs T, Bowling M, Austin S, Stefanescu M, et al. Quantitative whole-body magnetic resonance imaging in children with Pompe disease: Clinical tools to evaluate severity of muscle disease. JIMD Rep. 2021 Jan;57(1):94–101.
Fernandes, Samuela A., et al. “Quantitative whole-body magnetic resonance imaging in children with Pompe disease: Clinical tools to evaluate severity of muscle disease.JIMD Rep, vol. 57, no. 1, Jan. 2021, pp. 94–101. Pubmed, doi:10.1002/jmd2.12174.
Fernandes SA, Khan AA, Boggs T, Bowling M, Austin S, Stefanescu M, Case L, Kishnani PS. Quantitative whole-body magnetic resonance imaging in children with Pompe disease: Clinical tools to evaluate severity of muscle disease. JIMD Rep. 2021 Jan;57(1):94–101.

Published In

JIMD Rep

DOI

ISSN

2192-8304

Publication Date

January 2021

Volume

57

Issue

1

Start / End Page

94 / 101

Location

United States

Related Subject Headings

  • 3202 Clinical sciences