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Laura Elizabeth Case

Associate Professor in Orthopaedic Surgery
Orthopaedic Surgery, Physical Therapy
DUMC 104002, 2200 West Main Street, Suite A210, Erwin, Durham, NC 27708
Doctor of Physical Therapy Division, DUMC Box 104002, Durham, NC 27710

Overview


Laura E Case, PT, DPT, MS, PhD, PCS, C/NDT is a board-certified clinical specialist in pediatric physical therapy. She has dedicated her career to teaching, research in childhood-onset neuromusculoskeletal disorders, and to the lifelong treatment of people with childhood-onset neurological and neuromuscular disorders such as cerebral palsy, traumatic brain injury, Duchenne muscular dystrophy, spinal muscular atrophy, Pompe disease, myelodysplasia, juvenile rheumatoid arthritis, and brachial plexus injury.

She has been involved in numerous clinical trials for the treatment of disorders including Pompe disease and other metabolic disorders, cerebral palsy, Duchenne muscular dystrophy, and spinal muscular atrophy. Dr. Case has participated in the development of international guidelines for the management of Duchenne muscular dystrophy, Pompe disease, and other glycogen storage diseases.

She teaches and consults internationally, has worked on a number of Center for Disease Control (CDC) task forces, has served on numerous committees and task forces in the pediatric section of APTA, served two terms as NC State Representative to the APTA Section on Pediatrics, and is a member of the North American Pompe Registry Board of Advisors.

Current Appointments & Affiliations


Associate Professor in Orthopaedic Surgery · 2021 - Present Orthopaedic Surgery, Physical Therapy, Orthopaedic Surgery
Associate Professor in Pediatrics · 2021 - Present Pediatrics, Medical Genetics, Pediatrics

Recent Publications


Optimizing clinical outcomes: The journey of twins with CRIM-negative infantile-onset Pompe disease on high-dose enzyme replacement therapy and immunomodulation.

Journal Article Mol Genet Metab Rep · December 2024 Infantile-onset Pompe disease (IOPD) is caused by a deficiency in the enzyme acid alpha-glucosidase (GAA). It is characterized by severe and progressive hypertrophic cardiomyopathy and muscle weakness with death in the first 2 years of life if left untreat ... Full text Link to item Cite

IOPD entering adulthood: Lessons from two decades of ERT experience

Conference Molecular Genetics and Metabolism · February 2024 Full text Cite
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Recent Grants


Understanding cognitive and neurological pathologies in infantile Pompe disease CNS

Clinical TrialPhysical Therapist · Awarded by Genzyme Corporation · 2022 - 2030

Understanding cognitive and neurological pathologies in infantile Pompe disease CNS

Clinical TrialPhysical Therapist · Awarded by Genzyme Corporation · 2019 - 2021

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Education, Training & Certifications


Massachusetts General Hospital · 2005 D.P.T.
University of North Carolina, Chapel Hill · 1992 M.S.
Ithaca College · 1978 B.S.