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Disease Expression and Familial Transmission of Fuchs Endothelial Corneal Dystrophy With and Without CTG18.1 Expansion.

Publication ,  Journal Article
Xu, TT; Li, Y-J; Afshari, NA; Aleff, RA; Rinkoski, TA; Patel, SV; Maguire, LJ; Edwards, AO; Brown, WL; Fautsch, MP; Wieben, ED; Baratz, KH
Published in: Invest Ophthalmol Vis Sci
January 4, 2021

PURPOSE: To characterize inheritance, penetrance, and trinucleotide repeat expansion stability in Fuchs endothelial corneal dystrophy (FECD). METHODS: One thousand unrelated and related subjects with and without FECD were prospectively recruited. CTG18.1 repeat length (CTG18.1L) was determined via short tandem repeat assay and Southern blotting of leukocyte DNA. Multivariable logistic regression and generalized estimating equation models were employed. RESULTS: There were 546 unrelated FECD cases (67.6% female; 70 ± 10 years) and 235 controls (63.8% female; 73 ± 8 years; all ≥ 50 years). CTG18.1 expansion (CTG18.1exp+) was observed in 424 (77.7%) cases and 18 (7.7%) controls (P = 2.48 × 10-44). CTG18.1 expansion was associated with FECD severity (P = 5.62 × 10-7). The family arm of the study included 331 members from 112 FECD-affected families; 87 families were CTG18.1exp+. Autosomal dominant inheritance with variable expression of FECD was observed, regardless of expansion status. FECD penetrance of CTG18.1 expansion increased with age, ranging from 44.4% in the youngest (19-46 years) to 86.2% in the oldest (64-91 years) age quartiles. Among 62 parent-offspring transmissions of CTG18.1exp+, 48 (77.4%) had a change in CTG18.1L ≤ 10 repeats, and eight (12.9%) were ≥50 repeats, including five large expansions (∼1000-2000 repeats) that contracted. Among 44 offspring who did not inherit the CTG18.1exp+ allele, eight (18.2%) exhibited FECD. CONCLUSIONS: CTG18.1 expansion was highly associated with FECD but demonstrated incomplete penetrance. CTG18.1L instability occurred in a minority of parent-offspring transmissions, with large expansions exhibiting contraction. The observation of FECD without CTG18.1 expansion among family members in CTG18.1exp+ families highlights the complexity of the relationship between the FECD phenotype and CTG18.1 expansion.

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Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

January 4, 2021

Volume

62

Issue

1

Start / End Page

17

Location

United States

Related Subject Headings

  • Young Adult
  • Trinucleotide Repeat Expansion
  • Transcription Factor 4
  • Prospective Studies
  • Polymorphism, Genetic
  • Polymerase Chain Reaction
  • Penetrance
  • Pedigree
  • Ophthalmology & Optometry
  • Middle Aged
 

Citation

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Xu, T. T., Li, Y.-J., Afshari, N. A., Aleff, R. A., Rinkoski, T. A., Patel, S. V., … Baratz, K. H. (2021). Disease Expression and Familial Transmission of Fuchs Endothelial Corneal Dystrophy With and Without CTG18.1 Expansion. Invest Ophthalmol Vis Sci, 62(1), 17. https://doi.org/10.1167/iovs.62.1.17
Xu, Timothy T., Yi-Ju Li, Natalie A. Afshari, Ross A. Aleff, Tommy A. Rinkoski, Sanjay V. Patel, Leo J. Maguire, et al. “Disease Expression and Familial Transmission of Fuchs Endothelial Corneal Dystrophy With and Without CTG18.1 Expansion.Invest Ophthalmol Vis Sci 62, no. 1 (January 4, 2021): 17. https://doi.org/10.1167/iovs.62.1.17.
Xu TT, Li Y-J, Afshari NA, Aleff RA, Rinkoski TA, Patel SV, et al. Disease Expression and Familial Transmission of Fuchs Endothelial Corneal Dystrophy With and Without CTG18.1 Expansion. Invest Ophthalmol Vis Sci. 2021 Jan 4;62(1):17.
Xu, Timothy T., et al. “Disease Expression and Familial Transmission of Fuchs Endothelial Corneal Dystrophy With and Without CTG18.1 Expansion.Invest Ophthalmol Vis Sci, vol. 62, no. 1, Jan. 2021, p. 17. Pubmed, doi:10.1167/iovs.62.1.17.
Xu TT, Li Y-J, Afshari NA, Aleff RA, Rinkoski TA, Patel SV, Maguire LJ, Edwards AO, Brown WL, Fautsch MP, Wieben ED, Baratz KH. Disease Expression and Familial Transmission of Fuchs Endothelial Corneal Dystrophy With and Without CTG18.1 Expansion. Invest Ophthalmol Vis Sci. 2021 Jan 4;62(1):17.

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

January 4, 2021

Volume

62

Issue

1

Start / End Page

17

Location

United States

Related Subject Headings

  • Young Adult
  • Trinucleotide Repeat Expansion
  • Transcription Factor 4
  • Prospective Studies
  • Polymorphism, Genetic
  • Polymerase Chain Reaction
  • Penetrance
  • Pedigree
  • Ophthalmology & Optometry
  • Middle Aged