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Fueling Cell Invasion through Extracellular Matrix.

Publication ,  Journal Article
Garde, A; Sherwood, DR
Published in: Trends in cell biology
June 2021

Cell invasion through extracellular matrix (ECM) has pivotal roles in cell dispersal during development, immune cell trafficking, and cancer metastasis. Many elegant studies have revealed the specialized cellular protrusions, proteases, and distinct modes of migration invasive cells use to overcome ECM barriers. Less clear, however, is how invasive cells provide energy, specifically ATP, to power the energetically demanding membrane trafficking, F-actin polymerization, and actomyosin machinery that mediate break down, remodeling, and movement through ECMs. Here, we provide an overview of the challenges of examining ATP generation and delivery within invading cells and how recent studies using diverse invasion models, experimental approaches, and energy biosensors are revealing that energy metabolism is an integral component of cell invasive behavior that is dynamically tuned to overcome the ECM environment.

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Published In

Trends in cell biology

DOI

EISSN

1879-3088

ISSN

0962-8924

Publication Date

June 2021

Volume

31

Issue

6

Start / End Page

445 / 456

Related Subject Headings

  • Extracellular Matrix
  • Developmental Biology
  • Cell Movement
  • Actomyosin
  • Actins
  • 3101 Biochemistry and cell biology
  • 11 Medical and Health Sciences
  • 06 Biological Sciences
 

Citation

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Garde, A., & Sherwood, D. R. (2021). Fueling Cell Invasion through Extracellular Matrix. Trends in Cell Biology, 31(6), 445–456. https://doi.org/10.1016/j.tcb.2021.01.006
Garde, Aastha, and David R. Sherwood. “Fueling Cell Invasion through Extracellular Matrix.Trends in Cell Biology 31, no. 6 (June 2021): 445–56. https://doi.org/10.1016/j.tcb.2021.01.006.
Garde A, Sherwood DR. Fueling Cell Invasion through Extracellular Matrix. Trends in cell biology. 2021 Jun;31(6):445–56.
Garde, Aastha, and David R. Sherwood. “Fueling Cell Invasion through Extracellular Matrix.Trends in Cell Biology, vol. 31, no. 6, June 2021, pp. 445–56. Epmc, doi:10.1016/j.tcb.2021.01.006.
Garde A, Sherwood DR. Fueling Cell Invasion through Extracellular Matrix. Trends in cell biology. 2021 Jun;31(6):445–456.
Journal cover image

Published In

Trends in cell biology

DOI

EISSN

1879-3088

ISSN

0962-8924

Publication Date

June 2021

Volume

31

Issue

6

Start / End Page

445 / 456

Related Subject Headings

  • Extracellular Matrix
  • Developmental Biology
  • Cell Movement
  • Actomyosin
  • Actins
  • 3101 Biochemistry and cell biology
  • 11 Medical and Health Sciences
  • 06 Biological Sciences