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C. elegans as a model to study glial development.

Publication ,  Journal Article
Zhang, A; Yan, D
Published in: FEBS J
March 2022

Glia make up roughly half of all cells in the mammalian nervous system and play a major part in nervous system development, function, and disease. Although research in the past few decades has shed light on their morphological and functional diversity, there is still much to be known about key aspects of their development such as the generation of glial diversity and the factors governing proper morphogenesis. Glia of the nematode C. elegans possess many developmental and morphological similarities with their vertebrate counterparts and can potentially be used as a model to understand certain aspects of glial biology owing to advantages such as its genetic tractability and fully mapped cell lineage. In this review, we summarize recent progress in our understanding of genetic pathways that regulate glial development in C. elegans and discuss how some of these findings may be conserved.

Duke Scholars

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Published In

FEBS J

DOI

EISSN

1742-4658

Publication Date

March 2022

Volume

289

Issue

6

Start / End Page

1476 / 1485

Location

England

Related Subject Headings

  • Vertebrates
  • Neuroglia
  • Neurogenesis
  • Nematoda
  • Mammals
  • Caenorhabditis elegans
  • Biochemistry & Molecular Biology
  • Animals
  • 3404 Medicinal and biomolecular chemistry
  • 3205 Medical biochemistry and metabolomics
 

Citation

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Zhang, A., & Yan, D. (2022). C. elegans as a model to study glial development. FEBS J, 289(6), 1476–1485. https://doi.org/10.1111/febs.15758
Zhang, Albert, and Dong Yan. “C. elegans as a model to study glial development.FEBS J 289, no. 6 (March 2022): 1476–85. https://doi.org/10.1111/febs.15758.
Zhang A, Yan D. C. elegans as a model to study glial development. FEBS J. 2022 Mar;289(6):1476–85.
Zhang, Albert, and Dong Yan. “C. elegans as a model to study glial development.FEBS J, vol. 289, no. 6, Mar. 2022, pp. 1476–85. Pubmed, doi:10.1111/febs.15758.
Zhang A, Yan D. C. elegans as a model to study glial development. FEBS J. 2022 Mar;289(6):1476–1485.
Journal cover image

Published In

FEBS J

DOI

EISSN

1742-4658

Publication Date

March 2022

Volume

289

Issue

6

Start / End Page

1476 / 1485

Location

England

Related Subject Headings

  • Vertebrates
  • Neuroglia
  • Neurogenesis
  • Nematoda
  • Mammals
  • Caenorhabditis elegans
  • Biochemistry & Molecular Biology
  • Animals
  • 3404 Medicinal and biomolecular chemistry
  • 3205 Medical biochemistry and metabolomics