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Associations of Maternal Cardiovascular Health in Pregnancy With Offspring Cardiovascular Health in Early Adolescence.

Publication ,  Journal Article
Perak, AM; Lancki, N; Kuang, A; Labarthe, DR; Allen, NB; Shah, SH; Lowe, LP; Grobman, WA; Lawrence, JM; Lloyd-Jones, DM; Lowe, WL ...
Published in: JAMA
February 16, 2021

IMPORTANCE: Pregnancy may be a key window to optimize cardiovascular health (CVH) for the mother and influence lifelong CVH for her child. OBJECTIVE: To examine associations between maternal gestational CVH and offspring CVH. DESIGN, SETTING, AND PARTICIPANTS: This cohort study used data from the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study (examinations: July 2000-April 2006) and HAPO Follow-Up Study (examinations: February 2013-December 2016). The analyses included 2302 mother-child dyads, comprising 48% of HAPO Follow-Up Study participants, in an ancillary CVH study. Participants were from 9 field centers across the United States, Barbados, United Kingdom, China, Thailand, and Canada. EXPOSURES: Maternal gestational CVH at a target of 28 weeks' gestation, based on 5 metrics: body mass index, blood pressure, total cholesterol level, glucose level, and smoking. Each metric was categorized as ideal, intermediate, or poor using pregnancy guidelines. Total CVH was categorized as follows: all ideal metrics, 1 or more intermediate (but 0 poor) metrics, 1 poor metric, or 2 or more poor metrics. MAIN OUTCOMES AND MEASURES: Offspring CVH at ages 10 to 14 years, based on 4 metrics: body mass index, blood pressure, total cholesterol level, and glucose level. Total CVH was categorized as for mothers. RESULTS: Among 2302 dyads, the mean (SD) ages were 29.6 (2.7) years for pregnant mothers and 11.3 (1.1) years for children. During pregnancy, the mean (SD) maternal CVH score was 8.6 (1.4) out of 10. Among pregnant mothers, the prevalence of all ideal metrics was 32.8% (95% CI, 30.6%-35.1%), 31.7% (95% CI, 29.4%-34.0%) for 1 or more intermediate metrics, 29.5% (95% CI, 27.2%-31.7%) for 1 poor metric, and 6.0% (95% CI, 3.8%-8.3%) for 2 or more poor metrics. Among children of mothers with all ideal metrics, the prevalence of all ideal metrics was 42.2% (95% CI, 38.4%-46.2%), 36.7% (95% CI, 32.9%-40.7%) for 1 or more intermediate metrics, 18.4% (95% CI, 14.6%-22.4%) for 1 poor metric, and 2.6% (95% CI, 0%-6.6%) for 2 or more poor metrics. Among children of mothers with 2 or more poor metrics, the prevalence of all ideal metrics was 30.7% (95% CI, 22.0%-40.4%), 28.3% (95% CI, 19.7%-38.1%) for 1 or more intermediate metrics, 30.7% (95% CI, 22.0%-40.4%) for 1 poor metric, and 10.2% (95% CI, 1.6%-20.0%) for 2 or more poor metrics. The adjusted relative risks associated with 1 or more intermediate, 1 poor, and 2 or more poor (vs all ideal) metrics, respectively, in mothers during pregnancy were 1.17 (95% CI, 0.96-1.42), 1.66 (95% CI, 1.39-1.99), and 2.02 (95% CI, 1.55-2.64) for offspring to have 1 poor (vs all ideal) metrics, and the relative risks were 2.15 (95% CI, 1.23-3.75), 3.32 (95% CI,1.96-5.62), and 7.82 (95% CI, 4.12-14.85) for offspring to have 2 or more poor (vs all ideal) metrics. Additional adjustment for categorical birth factors (eg, preeclampsia) did not fully explain these significant associations (eg, relative risk for association between 2 or more poor metrics among mothers during pregnancy and 2 or more poor metrics among offspring after adjustment for an extended set of birth factors, 6.23 [95% CI, 3.03-12.82]). CONCLUSIONS AND RELEVANCE: In this multinational cohort, better maternal CVH at 28 weeks' gestation was significantly associated with better offspring CVH at ages 10 to 14 years.

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Published In

JAMA

DOI

EISSN

1538-3598

Publication Date

February 16, 2021

Volume

325

Issue

7

Start / End Page

658 / 668

Location

United States

Related Subject Headings

  • Prevalence
  • Pregnancy
  • Maternal Health
  • Male
  • Humans
  • Heart Disease Risk Factors
  • Health Behavior
  • General & Internal Medicine
  • Female
  • Cohort Studies
 

Citation

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MLA
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Perak, A. M., Lancki, N., Kuang, A., Labarthe, D. R., Allen, N. B., Shah, S. H., … HAPO Follow-Up Study Cooperative Research Group. (2021). Associations of Maternal Cardiovascular Health in Pregnancy With Offspring Cardiovascular Health in Early Adolescence. JAMA, 325(7), 658–668. https://doi.org/10.1001/jama.2021.0247
Perak, Amanda M., Nicola Lancki, Alan Kuang, Darwin R. Labarthe, Norrina B. Allen, Svati H. Shah, Lynn P. Lowe, et al. “Associations of Maternal Cardiovascular Health in Pregnancy With Offspring Cardiovascular Health in Early Adolescence.JAMA 325, no. 7 (February 16, 2021): 658–68. https://doi.org/10.1001/jama.2021.0247.
Perak AM, Lancki N, Kuang A, Labarthe DR, Allen NB, Shah SH, et al. Associations of Maternal Cardiovascular Health in Pregnancy With Offspring Cardiovascular Health in Early Adolescence. JAMA. 2021 Feb 16;325(7):658–68.
Perak, Amanda M., et al. “Associations of Maternal Cardiovascular Health in Pregnancy With Offspring Cardiovascular Health in Early Adolescence.JAMA, vol. 325, no. 7, Feb. 2021, pp. 658–68. Pubmed, doi:10.1001/jama.2021.0247.
Perak AM, Lancki N, Kuang A, Labarthe DR, Allen NB, Shah SH, Lowe LP, Grobman WA, Lawrence JM, Lloyd-Jones DM, Lowe WL, Scholtens DM, HAPO Follow-Up Study Cooperative Research Group. Associations of Maternal Cardiovascular Health in Pregnancy With Offspring Cardiovascular Health in Early Adolescence. JAMA. 2021 Feb 16;325(7):658–668.
Journal cover image

Published In

JAMA

DOI

EISSN

1538-3598

Publication Date

February 16, 2021

Volume

325

Issue

7

Start / End Page

658 / 668

Location

United States

Related Subject Headings

  • Prevalence
  • Pregnancy
  • Maternal Health
  • Male
  • Humans
  • Heart Disease Risk Factors
  • Health Behavior
  • General & Internal Medicine
  • Female
  • Cohort Studies