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Vitamin D has no impact on outcomes after HSCT in children-A retrospective study.

Publication ,  Journal Article
Bajwa, RPS; Taylor, K; Hoyt, A; Kamboj, MK; Stanek, J; Mahadeo, KM; Alsaedi, H; Abdel-Azim, H; O'Kane, S; Martin, PL; Stafford, LA; Dvorak, CC
Published in: Pediatr Transplant
June 2021

Vitamin D not only plays an important role in bone metabolism but is also involved in multiple immune-mediated processes in the body which may be adversely affected in those with low levels. Most pediatric studies evaluating the association of vitamin D in patients undergoing allogeneic HSCT are single-center studies. We present the results of retrospective study at 5 centers across the United States in pediatric patients undergoing allogeneic HSCT. (VDD) and (VDI) were defined by vitamin D levels of <20 ng/ml and 21-30 ng/ml, respectively. The mean vitamin D levels pre-HSCT, day +30, and +100 were suggestive of VDI, but normalized thereafter. We compared the transplant characteristics and outcomes in 233 patients with VDD and VDI and those with normal levels and found no statistical difference in neutrophil or platelet engraftment, infections (viral, bacterial, or fungal) post-HSCT, length of hospital stay during HSCT, graft failure, acute or chronic GvHD, survival at day +100 and 1 year, or relapse of primary malignancy. We conclude that VDI or deficiency does not affect any of the common transplant variables after allogeneic HSCT in children. There is a need of a large multicenter prospective study to evaluate its role further.

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Published In

Pediatr Transplant

DOI

EISSN

1399-3046

Publication Date

June 2021

Volume

25

Issue

4

Start / End Page

e14008

Location

Denmark

Related Subject Headings

  • Young Adult
  • Vitamin D Deficiency
  • Surgery
  • Risk Factors
  • Retrospective Studies
  • Recurrence
  • Outcome Assessment, Health Care
  • Male
  • Length of Stay
  • Kaplan-Meier Estimate
 

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Bajwa, R. P. S., Taylor, K., Hoyt, A., Kamboj, M. K., Stanek, J., Mahadeo, K. M., … Dvorak, C. C. (2021). Vitamin D has no impact on outcomes after HSCT in children-A retrospective study. Pediatr Transplant, 25(4), e14008. https://doi.org/10.1111/petr.14008
Bajwa, Rajinder P. S., Kimberly Taylor, Amanda Hoyt, Manmohan K. Kamboj, Joseph Stanek, Kris M. Mahadeo, Hawazen Alsaedi, et al. “Vitamin D has no impact on outcomes after HSCT in children-A retrospective study.Pediatr Transplant 25, no. 4 (June 2021): e14008. https://doi.org/10.1111/petr.14008.
Bajwa RPS, Taylor K, Hoyt A, Kamboj MK, Stanek J, Mahadeo KM, et al. Vitamin D has no impact on outcomes after HSCT in children-A retrospective study. Pediatr Transplant. 2021 Jun;25(4):e14008.
Bajwa, Rajinder P. S., et al. “Vitamin D has no impact on outcomes after HSCT in children-A retrospective study.Pediatr Transplant, vol. 25, no. 4, June 2021, p. e14008. Pubmed, doi:10.1111/petr.14008.
Bajwa RPS, Taylor K, Hoyt A, Kamboj MK, Stanek J, Mahadeo KM, Alsaedi H, Abdel-Azim H, O’Kane S, Martin PL, Stafford LA, Dvorak CC. Vitamin D has no impact on outcomes after HSCT in children-A retrospective study. Pediatr Transplant. 2021 Jun;25(4):e14008.

Published In

Pediatr Transplant

DOI

EISSN

1399-3046

Publication Date

June 2021

Volume

25

Issue

4

Start / End Page

e14008

Location

Denmark

Related Subject Headings

  • Young Adult
  • Vitamin D Deficiency
  • Surgery
  • Risk Factors
  • Retrospective Studies
  • Recurrence
  • Outcome Assessment, Health Care
  • Male
  • Length of Stay
  • Kaplan-Meier Estimate