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Incidence and Risk Factors for Postpartum Depression among Women with Preterm Prelabor Rupture of Membranes.

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Zemtsov, GE; Avram, CM; Darling, A; Dillon, J; Wheeler, S; Dotters-Katz, SK
Published in: Am J Perinatol
June 2022

OBJECTIVE: Patients admitted for preterm prelabor rupture of membranes are more likely to have risk factors for postpartum depression, including preterm delivery, low-birthweight infants, and a stressful life event. However, there is a paucity of data characterizing the development of postpartum depression in this population. We aim to evaluate the incidence of and describe risk factors for postpartum depression among patients admitted with preterm prelabor rupture of membranes. STUDY DESIGN: This is a retrospective cohort study of patients admitted for preterm prelabor rupture of membranes in a single health system between 2013 and 2019. Patients who developed depression were compared with patients who did not develop depression. Demographic, antepartum/intrapartum/postpartum, and neonatal characteristics were compared. Bivariate statistics were used to compare outcomes and logistic regression was used to estimate adjusted odds ratios. RESULTS: Of 132 included patients with preterm prelabor rupture of membranes, 25 (18.9%) had postpartum depression. Factors significantly (p < 0.05) associated with postpartum depression included history of depression, anxiety, or any prior mental health condition. Earlier admission gestational age, rupture of membranes < 28 weeks, earlier delivery gestational age, neonatal morbidity, and neonatal necrotizing enterocolitis also were significantly associated with postpartum depression. Latency, maternal postpartum length of stay, and neonatal intensive care unit length of stay were not significantly associated. In regression models, only a history of depression (odds ratio [OR], 11.89; 95% confidence interval [CI], 2.78-50.95) and neonatal morbidity (OR, 5.01; 95% CI, 1.15-21.89) remained associated with postpartum depression. CONCLUSION: Postpartum depression occurred in nearly one in five patients with preterm prelabor rupture of membranes. Pre-existing depression and adverse neonatal outcomes strongly predicted postpartum depression. There is an urgent need to prioritize maternal mental health among patients with preterm prelabor rupture of membranes in the peripartum period. Further research is needed to identify optimal resources for mitigating the risk of postpartum depression in this cohort. KEY POINTS: · After PPROM, postpartum depression is common.. · Maternal depression and neonatal morbidity are risk factors for PPD.. · Hospital admission permits intervention for PPD..

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Published In

Am J Perinatol

DOI

EISSN

1098-8785

Publication Date

June 2022

Volume

39

Issue

8

Start / End Page

797 / 802

Location

United States

Related Subject Headings

  • Risk Factors
  • Retrospective Studies
  • Pregnancy Outcome
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Infant, Newborn
  • Infant
  • Incidence
  • Humans
  • Gestational Age
 

Citation

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Chicago
ICMJE
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Zemtsov, G. E., Avram, C. M., Darling, A., Dillon, J., Wheeler, S., & Dotters-Katz, S. K. (2022). Incidence and Risk Factors for Postpartum Depression among Women with Preterm Prelabor Rupture of Membranes. In Am J Perinatol (Vol. 39, pp. 797–802). United States. https://doi.org/10.1055/s-0041-1740214
Zemtsov, Gregory E., Carmen M. Avram, Alice Darling, Jacquelyn Dillon, Sarahn Wheeler, and Sarah K. Dotters-Katz. “Incidence and Risk Factors for Postpartum Depression among Women with Preterm Prelabor Rupture of Membranes.” In Am J Perinatol, 39:797–802, 2022. https://doi.org/10.1055/s-0041-1740214.
Zemtsov GE, Avram CM, Darling A, Dillon J, Wheeler S, Dotters-Katz SK. Incidence and Risk Factors for Postpartum Depression among Women with Preterm Prelabor Rupture of Membranes. In: Am J Perinatol. 2022. p. 797–802.
Zemtsov, Gregory E., et al. “Incidence and Risk Factors for Postpartum Depression among Women with Preterm Prelabor Rupture of Membranes.Am J Perinatol, vol. 39, no. 8, 2022, pp. 797–802. Pubmed, doi:10.1055/s-0041-1740214.
Zemtsov GE, Avram CM, Darling A, Dillon J, Wheeler S, Dotters-Katz SK. Incidence and Risk Factors for Postpartum Depression among Women with Preterm Prelabor Rupture of Membranes. Am J Perinatol. 2022. p. 797–802.
Journal cover image

Published In

Am J Perinatol

DOI

EISSN

1098-8785

Publication Date

June 2022

Volume

39

Issue

8

Start / End Page

797 / 802

Location

United States

Related Subject Headings

  • Risk Factors
  • Retrospective Studies
  • Pregnancy Outcome
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Infant, Newborn
  • Infant
  • Incidence
  • Humans
  • Gestational Age