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Ethnic difference of thrombogenicity in patients with cardiovascular disease: A pandora box to explain prognostic differences

Publication ,  Journal Article
Kim, HK; Tantry, US; Park, HW; Shin, ES; Geisler, T; Gorog, DA; Gurbel, PA; Jeong, YH
Published in: Korean Circulation Journal
February 1, 2021

Arterial and venous atherothrombotic events are finely regulated processes involving a complex interplay between vulnerable blood, vulnerable vessel, and blood stasis. Vulnerable blood ('thrombogenicity') comprises complex interactions between cellular components and plasma factors (inflammatory, procoagulant, anticoagulant, and fibrinolytic factors). The extent of thrombogenicity may determine the progression of atheroma and the clinical manifestation of atherothrombotic events, with the highest thrombogenicity in African Americans and lowest in East Asians. Inherent thrombogenicity may influence clinical efficacy and safety of specific antithrombotic treatments in high-risk patients, which may in part explain the observation that East Asian patients have reduced anti-ischemic benefits and elevated bleeding risk with antithrombotic therapy compared to Caucasian patients. In this review, we discuss available evidence regarding the racial differences in thrombogenicity and its impact on clinical outcomes among patients with atherosclerotic cardiovascular disease.

Duke Scholars

Published In

Korean Circulation Journal

DOI

EISSN

1738-5555

ISSN

1738-5520

Publication Date

February 1, 2021

Volume

51

Issue

3

Start / End Page

202 / 221
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kim, H. K., Tantry, U. S., Park, H. W., Shin, E. S., Geisler, T., Gorog, D. A., … Jeong, Y. H. (2021). Ethnic difference of thrombogenicity in patients with cardiovascular disease: A pandora box to explain prognostic differences. Korean Circulation Journal, 51(3), 202–221. https://doi.org/10.4070/KCJ.2020.0537
Kim, H. K., U. S. Tantry, H. W. Park, E. S. Shin, T. Geisler, D. A. Gorog, P. A. Gurbel, and Y. H. Jeong. “Ethnic difference of thrombogenicity in patients with cardiovascular disease: A pandora box to explain prognostic differences.” Korean Circulation Journal 51, no. 3 (February 1, 2021): 202–21. https://doi.org/10.4070/KCJ.2020.0537.
Kim HK, Tantry US, Park HW, Shin ES, Geisler T, Gorog DA, et al. Ethnic difference of thrombogenicity in patients with cardiovascular disease: A pandora box to explain prognostic differences. Korean Circulation Journal. 2021 Feb 1;51(3):202–21.
Kim, H. K., et al. “Ethnic difference of thrombogenicity in patients with cardiovascular disease: A pandora box to explain prognostic differences.” Korean Circulation Journal, vol. 51, no. 3, Feb. 2021, pp. 202–21. Scopus, doi:10.4070/KCJ.2020.0537.
Kim HK, Tantry US, Park HW, Shin ES, Geisler T, Gorog DA, Gurbel PA, Jeong YH. Ethnic difference of thrombogenicity in patients with cardiovascular disease: A pandora box to explain prognostic differences. Korean Circulation Journal. 2021 Feb 1;51(3):202–221.

Published In

Korean Circulation Journal

DOI

EISSN

1738-5555

ISSN

1738-5520

Publication Date

February 1, 2021

Volume

51

Issue

3

Start / End Page

202 / 221