Paget's Disease of Bone: Osteoimmunology and Osteoclast Pathology.
Publication
, Journal Article
Rabjohns, EM; Hurst, K; Ghosh, A; Cuellar, MC; Rampersad, RR; Tarrant, TK
Published in: Curr Allergy Asthma Rep
March 25, 2021
PURPOSE OF REVIEW: The purpose of this review is to recognize clinical features of Paget's disease of bone and to describe how the osteoclast, a myeloid-derived cell responsible for bone resorption, contributes to the disease. RECENT FINDINGS: Recent studies have identified several variants in SQSTM1, OPTN, and other genes that may predispose individuals to Paget's disease of bone; studies of these genes and their protein products have elucidated new roles for these proteins in bone physiology. Understanding the pathologic mechanisms in the Pagetic osteoclast may lead to the identification of future treatment targets for other inflammatory and autoimmune diseases characterized by abnormal bone erosion and/or osteoclast activation.
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Published In
Curr Allergy Asthma Rep
DOI
EISSN
1534-6315
Publication Date
March 25, 2021
Volume
21
Issue
4
Start / End Page
23
Location
United States
Related Subject Headings
- Osteoclasts
- Osteitis Deformans
- Humans
- Bone and Bones
- Bone Remodeling
- Allergy
- Algorithms
- 3204 Immunology
- 3201 Cardiovascular medicine and haematology
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Chicago
ICMJE
MLA
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Rabjohns, E. M., Hurst, K., Ghosh, A., Cuellar, M. C., Rampersad, R. R., & Tarrant, T. K. (2021). Paget's Disease of Bone: Osteoimmunology and Osteoclast Pathology. Curr Allergy Asthma Rep, 21(4), 23. https://doi.org/10.1007/s11882-021-01001-2
Rabjohns, Emily M., Katlyn Hurst, Arin Ghosh, Maria C. Cuellar, Rishi R. Rampersad, and Teresa K. Tarrant. “Paget's Disease of Bone: Osteoimmunology and Osteoclast Pathology.” Curr Allergy Asthma Rep 21, no. 4 (March 25, 2021): 23. https://doi.org/10.1007/s11882-021-01001-2.
Rabjohns EM, Hurst K, Ghosh A, Cuellar MC, Rampersad RR, Tarrant TK. Paget's Disease of Bone: Osteoimmunology and Osteoclast Pathology. Curr Allergy Asthma Rep. 2021 Mar 25;21(4):23.
Rabjohns, Emily M., et al. “Paget's Disease of Bone: Osteoimmunology and Osteoclast Pathology.” Curr Allergy Asthma Rep, vol. 21, no. 4, Mar. 2021, p. 23. Pubmed, doi:10.1007/s11882-021-01001-2.
Rabjohns EM, Hurst K, Ghosh A, Cuellar MC, Rampersad RR, Tarrant TK. Paget's Disease of Bone: Osteoimmunology and Osteoclast Pathology. Curr Allergy Asthma Rep. 2021 Mar 25;21(4):23.
Published In
Curr Allergy Asthma Rep
DOI
EISSN
1534-6315
Publication Date
March 25, 2021
Volume
21
Issue
4
Start / End Page
23
Location
United States
Related Subject Headings
- Osteoclasts
- Osteitis Deformans
- Humans
- Bone and Bones
- Bone Remodeling
- Allergy
- Algorithms
- 3204 Immunology
- 3201 Cardiovascular medicine and haematology