Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel

Pregnancy outcomes among women with class III obesity with normal early glucola.

Publication ,  Journal Article
Ellett, T; Mitchell, CJ; Dillon, J; Siegel, A; Denoble, AE; Dotters-Katz, S
Published in: J Matern Fetal Neonatal Med
December 2022

BACKGROUND: Because obese women are at increased risk for insulin resistance and development gestational diabetes (GDM), the American College of Obstetricians and Gynecologists (ACOG) recommends early GDM screening in this population. For obese women with a normal early 1-hour 50 g oral glucose challenge test (eGCT), the risk of developing GDM later in the pregnancy is unknown. Thus, we aimed to assess the risk of developing gestational diabetes based on the value of a normal eGCT. STUDY DESIGN: Retrospective cohort of non-anomalous singleton pregnancies with maternal body mass index (BMI) ≥40 at the time of entry to prenatal care at a single institution from 2013 to 2017. Pregnancies with abnormal early 1-hour 50 g glucose challenge test (eGCT), multiple gestation, late entry to care, type 1 or 2 diabetes, and missing diabetes-screening information are excluded. Primary outcome was development of GDM. Secondary outcomes include fetal growth restriction, macrosomia, gestational age at delivery, large for gestational age, delivery BMI, total weight gain in pregnancy, induction of labor, shoulder dystocia, and cesarean delivery. Bivariate statistics compare demographics, pregnancy complications and delivery characteristics of women who had an eGCT≤ 100 mg/dL (low-normal eGCT) and women who had an eGCT of 101-134 mg/dL (high-normal eGCT). Regression models used to estimate odds of primary outcome. RESULTS: Of 169 women, 66(39%) had a low-normal eGCT, and 103(61%) had a high-normal eGCT. Women in the low-normal eGCT group were more likely to use recreational drugs (p = 0.03), other baseline demographics did not differ. The rate of GDM was low in this population (5.3%), with no difference in the rate of GDM between with a low-normal eGCT (1.5%) and high-normal eGCT (7.7%) (p = 0.09). The median neonatal birthweight was higher in the high-normal GCT group (3405 g) as compared to the low-no GCT (3285 g) (p = 0.03). CONCLUSIONS: Among women with class 3 obesity, the specific value of an early normal GCT was not associated with developing gestational diabetes mellitus later in the pregnancy. Larger studies are needed confirm these findings.

Duke Scholars

Published In

J Matern Fetal Neonatal Med

DOI

EISSN

1476-4954

Publication Date

December 2022

Volume

35

Issue

25

Start / End Page

5834 / 5839

Location

England

Related Subject Headings

  • Weight Gain
  • Retrospective Studies
  • Pregnancy Outcome
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Obesity
  • Infant, Newborn
  • Humans
  • Glucose
  • Fetal Macrosomia
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ellett, T., Mitchell, C. J., Dillon, J., Siegel, A., Denoble, A. E., & Dotters-Katz, S. (2022). Pregnancy outcomes among women with class III obesity with normal early glucola. J Matern Fetal Neonatal Med, 35(25), 5834–5839. https://doi.org/10.1080/14767058.2021.1895741
Ellett, Tressa, Courtney J. Mitchell, Jacquelyn Dillon, Anne Siegel, Anna E. Denoble, and Sarah Dotters-Katz. “Pregnancy outcomes among women with class III obesity with normal early glucola.J Matern Fetal Neonatal Med 35, no. 25 (December 2022): 5834–39. https://doi.org/10.1080/14767058.2021.1895741.
Ellett T, Mitchell CJ, Dillon J, Siegel A, Denoble AE, Dotters-Katz S. Pregnancy outcomes among women with class III obesity with normal early glucola. J Matern Fetal Neonatal Med. 2022 Dec;35(25):5834–9.
Ellett, Tressa, et al. “Pregnancy outcomes among women with class III obesity with normal early glucola.J Matern Fetal Neonatal Med, vol. 35, no. 25, Dec. 2022, pp. 5834–39. Pubmed, doi:10.1080/14767058.2021.1895741.
Ellett T, Mitchell CJ, Dillon J, Siegel A, Denoble AE, Dotters-Katz S. Pregnancy outcomes among women with class III obesity with normal early glucola. J Matern Fetal Neonatal Med. 2022 Dec;35(25):5834–5839.

Published In

J Matern Fetal Neonatal Med

DOI

EISSN

1476-4954

Publication Date

December 2022

Volume

35

Issue

25

Start / End Page

5834 / 5839

Location

England

Related Subject Headings

  • Weight Gain
  • Retrospective Studies
  • Pregnancy Outcome
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Obesity
  • Infant, Newborn
  • Humans
  • Glucose
  • Fetal Macrosomia