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Outcomes and Health Care Resource Utilization of Adult Bacterial Meningitis in the United States.

Publication ,  Journal Article
Kiyani, M; Hodges, SE; Adil, SM; Charalambous, LT; Liu, B; Lee, H-J; Parente, B; Perfect, JR; Lad, SP
Published in: Neurol Clin Pract
April 2021

OBJECTIVE: To examine the longitudinal health care resource utilization, in-hospital mortality, and incidence of downstream complications of bacterial meningitis in the United States. METHODS: Using IBM MarketScan, we retrieved data on adult patients with a diagnosis of bacterial meningitis admitted to a US hospital between 2008 and 2015. Patients were stratified into groups (1) with/without prior head trauma/neurosurgical complications, (2) nosocomial/community acquisition, and (3) Gram-negative/positive bacteria. Cost data were collected for up to 2 years and analyzed with descriptive statistics and longitudinal modeling. RESULTS: Among 4,496 patients with bacterial meningitis, 16.5% and 4.6% had preceding neurosurgical complications and head injuries, respectively. Lumbar punctures were performed in 37.3% of patients without prior trauma/complications who went on to develop nosocomial meningitis, and those with prior head injuries or complications had longer initial hospital stays (17.0 days vs 8.0 days). Within a month of diagnosis, 29.2% of patients with bacterial meningitis had experienced downstream complications, most commonly hydrocephalus (12.7%). The worst 30-day mortality was due to tuberculous (12.3%) and streptococcal meningitis (7.2%). Overall, prior head trauma and complications were associated with higher costs. Community-acquired bacterial meningitis had lower median baseline costs relative to the nosocomial group (no head trauma/complication: $17,152 vs $82,778; head trauma/complication: $92,428 vs $168,309) but higher median costs within 3 months of diagnosis (no head trauma/complication: $47,911 vs $34,202; head trauma/complication: $89,207 vs $58,947). All costs demonstrated a sharp decline thereafter. CONCLUSIONS: Bacterial meningitis remains costly and devastating, especially for those who experience traumatic head injuries or have a complicated progress after neurosurgery.

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Published In

Neurol Clin Pract

DOI

ISSN

2163-0402

Publication Date

April 2021

Volume

11

Issue

2

Start / End Page

117 / 126

Location

United States

Related Subject Headings

  • 3209 Neurosciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kiyani, M., Hodges, S. E., Adil, S. M., Charalambous, L. T., Liu, B., Lee, H.-J., … Lad, S. P. (2021). Outcomes and Health Care Resource Utilization of Adult Bacterial Meningitis in the United States. Neurol Clin Pract, 11(2), 117–126. https://doi.org/10.1212/CPJ.0000000000000868
Kiyani, Musa, Sarah E. Hodges, Syed M. Adil, Lefko T. Charalambous, Beiyu Liu, Hui-Jie Lee, Beth Parente, John R. Perfect, and Shivanand P. Lad. “Outcomes and Health Care Resource Utilization of Adult Bacterial Meningitis in the United States.Neurol Clin Pract 11, no. 2 (April 2021): 117–26. https://doi.org/10.1212/CPJ.0000000000000868.
Kiyani M, Hodges SE, Adil SM, Charalambous LT, Liu B, Lee H-J, et al. Outcomes and Health Care Resource Utilization of Adult Bacterial Meningitis in the United States. Neurol Clin Pract. 2021 Apr;11(2):117–26.
Kiyani, Musa, et al. “Outcomes and Health Care Resource Utilization of Adult Bacterial Meningitis in the United States.Neurol Clin Pract, vol. 11, no. 2, Apr. 2021, pp. 117–26. Pubmed, doi:10.1212/CPJ.0000000000000868.
Kiyani M, Hodges SE, Adil SM, Charalambous LT, Liu B, Lee H-J, Parente B, Perfect JR, Lad SP. Outcomes and Health Care Resource Utilization of Adult Bacterial Meningitis in the United States. Neurol Clin Pract. 2021 Apr;11(2):117–126.

Published In

Neurol Clin Pract

DOI

ISSN

2163-0402

Publication Date

April 2021

Volume

11

Issue

2

Start / End Page

117 / 126

Location

United States

Related Subject Headings

  • 3209 Neurosciences