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Concerted morphogenesis of genital ridges and nephric ducts in the mouse captured through whole-embryo imaging.

Publication ,  Journal Article
Bunce, C; McKey, J; Capel, B
Published in: Development
September 15, 2021

During development of the mouse urogenital complex, the gonads undergo changes in three-dimensional structure, body position and spatial relationship with the mesonephric ducts, kidneys and adrenals. The complexity of genital ridge development obscures potential connections between morphogenesis and gonadal sex determination. To characterize the morphogenic processes implicated in regulating gonad shape and fate, we used whole-embryo tissue clearing and light sheet microscopy to assemble a time course of gonad development in native form and context. Analysis revealed that gonad morphology is determined through anterior-to-posterior patterns as well as increased rates of growth, rotation and separation in the central domain that may contribute to regionalization of the gonad. We report a close alignment of gonad and mesonephric duct movements as well as delayed duct development in a gonad dysgenesis mutant, which together support a mechanical dependency linking gonad and mesonephric duct morphogenesis.

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Published In

Development

DOI

EISSN

1477-9129

Publication Date

September 15, 2021

Volume

148

Issue

18

Location

England

Related Subject Headings

  • Wolffian Ducts
  • Sex Differentiation
  • Morphogenesis
  • Mice, Inbred C57BL
  • Mice
  • Mesonephros
  • Male
  • Kidney
  • Gonads
  • Gestational Age
 

Citation

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MLA
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Bunce, C., McKey, J., & Capel, B. (2021). Concerted morphogenesis of genital ridges and nephric ducts in the mouse captured through whole-embryo imaging. Development, 148(18). https://doi.org/10.1242/dev.199208
Bunce, Corey, Jennifer McKey, and Blanche Capel. “Concerted morphogenesis of genital ridges and nephric ducts in the mouse captured through whole-embryo imaging.Development 148, no. 18 (September 15, 2021). https://doi.org/10.1242/dev.199208.
Bunce, Corey, et al. “Concerted morphogenesis of genital ridges and nephric ducts in the mouse captured through whole-embryo imaging.Development, vol. 148, no. 18, Sept. 2021. Pubmed, doi:10.1242/dev.199208.
Journal cover image

Published In

Development

DOI

EISSN

1477-9129

Publication Date

September 15, 2021

Volume

148

Issue

18

Location

England

Related Subject Headings

  • Wolffian Ducts
  • Sex Differentiation
  • Morphogenesis
  • Mice, Inbred C57BL
  • Mice
  • Mesonephros
  • Male
  • Kidney
  • Gonads
  • Gestational Age