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Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus.

Publication ,  Journal Article
Rausch, K; Hackett, BA; Weinbren, NL; Reeder, SM; Sadovsky, Y; Hunter, CA; Schultz, DC; Coyne, CB; Cherry, S
Published in: Cell Rep
January 17, 2017

Zika virus is an emerging arthropod-borne flavivirus for which there are no vaccines or specific therapeutics. We screened a library of 2,000 bioactive compounds for their ability to block Zika virus infection in three distinct cell types with two different strains of Zika virus. Using a microscopy-based assay, we validated 38 drugs that inhibited Zika virus infection, including FDA-approved nucleoside analogs. Cells expressing high levels of the attachment factor AXL can be protected from infection with receptor tyrosine kinase inhibitors, while placental-derived cells that lack AXL expression are insensitive to this inhibition. Importantly, we identified nanchangmycin as a potent inhibitor of Zika virus entry across all cell types tested, including physiologically relevant primary cells. Nanchangmycin also was active against other medically relevant viruses, including West Nile, dengue, and chikungunya viruses that use a similar route of entry. This study provides a resource of small molecules to study Zika virus pathogenesis.

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Published In

Cell Rep

DOI

EISSN

2211-1247

Publication Date

January 17, 2017

Volume

18

Issue

3

Start / End Page

804 / 815

Location

United States

Related Subject Headings

  • Zika Virus
  • West Nile virus
  • Virus Internalization
  • Trophoblasts
  • Spiro Compounds
  • Small Molecule Libraries
  • Nucleosides
  • Humans
  • Ethers
  • Endothelial Cells
 

Citation

APA
Chicago
ICMJE
MLA
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Rausch, K., Hackett, B. A., Weinbren, N. L., Reeder, S. M., Sadovsky, Y., Hunter, C. A., … Cherry, S. (2017). Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus. Cell Rep, 18(3), 804–815. https://doi.org/10.1016/j.celrep.2016.12.068
Rausch, Keiko, Brent A. Hackett, Nathan L. Weinbren, Sophia M. Reeder, Yoel Sadovsky, Christopher A. Hunter, David C. Schultz, Carolyn B. Coyne, and Sara Cherry. “Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus.Cell Rep 18, no. 3 (January 17, 2017): 804–15. https://doi.org/10.1016/j.celrep.2016.12.068.
Rausch K, Hackett BA, Weinbren NL, Reeder SM, Sadovsky Y, Hunter CA, et al. Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus. Cell Rep. 2017 Jan 17;18(3):804–15.
Rausch, Keiko, et al. “Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus.Cell Rep, vol. 18, no. 3, Jan. 2017, pp. 804–15. Pubmed, doi:10.1016/j.celrep.2016.12.068.
Rausch K, Hackett BA, Weinbren NL, Reeder SM, Sadovsky Y, Hunter CA, Schultz DC, Coyne CB, Cherry S. Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus. Cell Rep. 2017 Jan 17;18(3):804–815.
Journal cover image

Published In

Cell Rep

DOI

EISSN

2211-1247

Publication Date

January 17, 2017

Volume

18

Issue

3

Start / End Page

804 / 815

Location

United States

Related Subject Headings

  • Zika Virus
  • West Nile virus
  • Virus Internalization
  • Trophoblasts
  • Spiro Compounds
  • Small Molecule Libraries
  • Nucleosides
  • Humans
  • Ethers
  • Endothelial Cells