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Emerging Role of PD-1 in the Central Nervous System and Brain Diseases.

Publication ,  Journal Article
Zhao, J; Roberts, A; Wang, Z; Savage, J; Ji, R-R
Published in: Neurosci Bull
August 2021

Programmed cell death protein 1 (PD-1) is an immune checkpoint modulator and a major target of immunotherapy as anti-PD-1 monoclonal antibodies have demonstrated remarkable efficacy in cancer treatment. Accumulating evidence suggests an important role of PD-1 in the central nervous system (CNS). PD-1 has been implicated in CNS disorders such as brain tumors, Alzheimer's disease, ischemic stroke, spinal cord injury, multiple sclerosis, cognitive function, and pain. PD-1 signaling suppresses the CNS immune response via resident microglia and infiltrating peripheral immune cells. Notably, PD-1 is also widely expressed in neurons and suppresses neuronal activity via downstream Src homology 2 domain-containing protein tyrosine phosphatase 1 and modulation of ion channel function. An improved understanding of PD-1 signaling in the cross-talk between glial cells, neurons, and peripheral immune cells in the CNS will shed light on immunomodulation, neuromodulation, and novel strategies for treating brain diseases.

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Published In

Neurosci Bull

DOI

EISSN

1995-8218

Publication Date

August 2021

Volume

37

Issue

8

Start / End Page

1188 / 1202

Location

Singapore

Related Subject Headings

  • Programmed Cell Death 1 Receptor
  • Neurology & Neurosurgery
  • Neuroglia
  • Microglia
  • Humans
  • Central Nervous System
  • Brain Diseases
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zhao, J., Roberts, A., Wang, Z., Savage, J., & Ji, R.-R. (2021). Emerging Role of PD-1 in the Central Nervous System and Brain Diseases. Neurosci Bull, 37(8), 1188–1202. https://doi.org/10.1007/s12264-021-00683-y
Zhao, Junli, Alexus Roberts, Zilong Wang, Justin Savage, and Ru-Rong Ji. “Emerging Role of PD-1 in the Central Nervous System and Brain Diseases.Neurosci Bull 37, no. 8 (August 2021): 1188–1202. https://doi.org/10.1007/s12264-021-00683-y.
Zhao J, Roberts A, Wang Z, Savage J, Ji R-R. Emerging Role of PD-1 in the Central Nervous System and Brain Diseases. Neurosci Bull. 2021 Aug;37(8):1188–202.
Zhao, Junli, et al. “Emerging Role of PD-1 in the Central Nervous System and Brain Diseases.Neurosci Bull, vol. 37, no. 8, Aug. 2021, pp. 1188–202. Pubmed, doi:10.1007/s12264-021-00683-y.
Zhao J, Roberts A, Wang Z, Savage J, Ji R-R. Emerging Role of PD-1 in the Central Nervous System and Brain Diseases. Neurosci Bull. 2021 Aug;37(8):1188–1202.
Journal cover image

Published In

Neurosci Bull

DOI

EISSN

1995-8218

Publication Date

August 2021

Volume

37

Issue

8

Start / End Page

1188 / 1202

Location

Singapore

Related Subject Headings

  • Programmed Cell Death 1 Receptor
  • Neurology & Neurosurgery
  • Neuroglia
  • Microglia
  • Humans
  • Central Nervous System
  • Brain Diseases
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 1702 Cognitive Sciences