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Midlife Cardiovascular Fitness Is Reflected in the Brain's White Matter.

Publication ,  Journal Article
d'Arbeloff, T; Elliott, ML; Knodt, AR; Sison, M; Melzer, TR; Ireland, D; Ramrakha, S; Poulton, R; Caspi, A; Moffitt, TE; Hariri, AR
Published in: Frontiers in aging neuroscience
January 2021

Disappointing results from clinical trials designed to delay structural brain decline and the accompanying increase in risk for dementia in older adults have precipitated a shift in testing promising interventions from late in life toward midlife before irreversible damage has accumulated. This shift, however, requires targeting midlife biomarkers that are associated with clinical changes manifesting only in late life. Here we explored possible links between one putative biomarker, distributed integrity of brain white matter, and two intervention targets, cardiovascular fitness and healthy lifestyle behaviors, in midlife. At age 45, fractional anisotropy (FA) derived from diffusion weighted MRI was used to estimate the microstructural integrity of distributed white matter tracts in a population-representative birth cohort. Age-45 cardiovascular fitness (VO2Max; N = 801) was estimated from heart rates obtained during submaximal exercise tests; age-45 healthy lifestyle behaviors were estimated using the Nyberg Health Index (N = 854). Ten-fold cross-validated elastic net predictive modeling revealed that estimated VO2Max was modestly associated with distributed FA. In contrast, there was no significant association between Nyberg Health Index scores and FA. Our findings suggest that cardiovascular fitness levels, but not healthy lifestyle behaviors, are associated with the distributed integrity of white matter in the brain in midlife. These patterns could help inform future clinical intervention research targeting ADRDs.

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Published In

Frontiers in aging neuroscience

DOI

EISSN

1663-4365

ISSN

1663-4365

Publication Date

January 2021

Volume

13

Start / End Page

652575

Related Subject Headings

  • 5202 Biological psychology
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
  • 1109 Neurosciences
  • 0601 Biochemistry and Cell Biology
 

Citation

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d’Arbeloff, T., Elliott, M. L., Knodt, A. R., Sison, M., Melzer, T. R., Ireland, D., … Hariri, A. R. (2021). Midlife Cardiovascular Fitness Is Reflected in the Brain's White Matter. Frontiers in Aging Neuroscience, 13, 652575. https://doi.org/10.3389/fnagi.2021.652575
Arbeloff, Tracy d’, Maxwell L. Elliott, Annchen R. Knodt, Maria Sison, Tracy R. Melzer, David Ireland, Sandhya Ramrakha, et al. “Midlife Cardiovascular Fitness Is Reflected in the Brain's White Matter.Frontiers in Aging Neuroscience 13 (January 2021): 652575. https://doi.org/10.3389/fnagi.2021.652575.
d’Arbeloff T, Elliott ML, Knodt AR, Sison M, Melzer TR, Ireland D, et al. Midlife Cardiovascular Fitness Is Reflected in the Brain's White Matter. Frontiers in aging neuroscience. 2021 Jan;13:652575.
d’Arbeloff, Tracy, et al. “Midlife Cardiovascular Fitness Is Reflected in the Brain's White Matter.Frontiers in Aging Neuroscience, vol. 13, Jan. 2021, p. 652575. Epmc, doi:10.3389/fnagi.2021.652575.
d’Arbeloff T, Elliott ML, Knodt AR, Sison M, Melzer TR, Ireland D, Ramrakha S, Poulton R, Caspi A, Moffitt TE, Hariri AR. Midlife Cardiovascular Fitness Is Reflected in the Brain's White Matter. Frontiers in aging neuroscience. 2021 Jan;13:652575.

Published In

Frontiers in aging neuroscience

DOI

EISSN

1663-4365

ISSN

1663-4365

Publication Date

January 2021

Volume

13

Start / End Page

652575

Related Subject Headings

  • 5202 Biological psychology
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
  • 1109 Neurosciences
  • 0601 Biochemistry and Cell Biology