Synthetic efforts toward the bicyclo[3.2.1]octane fragment of rhodojaponin III.
Publication
, Journal Article
Webster, CG; Park, H; Ennis, AF; Hong, J
Published in: Tetrahedron letters
May 2021
Rhodojaponin III is a grayanane-type diterpenoid natural product with a novel chemical scaffold. It shows potent antinociceptive activity and may represent a new class of natural non-opioid analgesics with a novel mode of action. We explored the Au(I)-catalyzed Conia-ene cyclization and the Mn(III)-mediated radical cyclization of alkynyl ketones for the synthesis of the bicyclo[3.2.1]octane fragment of rhodojaponin III. These strategies will be applicable in the synthesis of rhodojaponin III and analogs for future biological studies.
Duke Scholars
Published In
Tetrahedron letters
DOI
ISSN
0040-4039
Publication Date
May 2021
Volume
71
Start / End Page
153055
Related Subject Headings
- Organic Chemistry
- 3405 Organic chemistry
- 3404 Medicinal and biomolecular chemistry
- 3101 Biochemistry and cell biology
- 0305 Organic Chemistry
- 0304 Medicinal and Biomolecular Chemistry
Citation
APA
Chicago
ICMJE
MLA
NLM
Webster, C. G., Park, H., Ennis, A. F., & Hong, J. (2021). Synthetic efforts toward the bicyclo[3.2.1]octane fragment of rhodojaponin III. Tetrahedron Letters, 71, 153055. https://doi.org/10.1016/j.tetlet.2021.153055
Webster, Caroline G., Hyeri Park, Amanda F. Ennis, and Jiyong Hong. “Synthetic efforts toward the bicyclo[3.2.1]octane fragment of rhodojaponin III.” Tetrahedron Letters 71 (May 2021): 153055. https://doi.org/10.1016/j.tetlet.2021.153055.
Webster CG, Park H, Ennis AF, Hong J. Synthetic efforts toward the bicyclo[3.2.1]octane fragment of rhodojaponin III. Tetrahedron letters. 2021 May;71:153055.
Webster, Caroline G., et al. “Synthetic efforts toward the bicyclo[3.2.1]octane fragment of rhodojaponin III.” Tetrahedron Letters, vol. 71, May 2021, p. 153055. Epmc, doi:10.1016/j.tetlet.2021.153055.
Webster CG, Park H, Ennis AF, Hong J. Synthetic efforts toward the bicyclo[3.2.1]octane fragment of rhodojaponin III. Tetrahedron letters. 2021 May;71:153055.
Published In
Tetrahedron letters
DOI
ISSN
0040-4039
Publication Date
May 2021
Volume
71
Start / End Page
153055
Related Subject Headings
- Organic Chemistry
- 3405 Organic chemistry
- 3404 Medicinal and biomolecular chemistry
- 3101 Biochemistry and cell biology
- 0305 Organic Chemistry
- 0304 Medicinal and Biomolecular Chemistry