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Celiac disease is not more prevalent in patients undergoing in vitro fertilization and does not affect reproductive outcomes with or without treatment: a large prospective cohort study.

Publication ,  Journal Article
Juneau, CR; Franasiak, JM; Goodman, LR; Marin, D; Scott, K; Morin, SJ; Neal, SA; Juneau, JE; Scott, RT
Published in: Fertil Steril
August 2018

OBJECTIVE: To study the prevalence of celiac disease in the infertile population undergoing in vitro fertilization (IVF) and assess outcomes. DESIGN: Prospective cohort study. SETTING: A single infertility center from January 2016 to March 2017. PATIENT(S): Women 18-45 years of age participating in IVF. INTERVENTION(S): Patients had serum tissue transglutaminase (tTG) and endomysial (EMA) IgA testing to screen for celiac disease and completed a 10-question "yes or no" survey to assess their medical history, previous testing, dietary habits, and pertinent symptoms. MAIN OUTCOME MEASURE(S): IVF cycle outcomes were compared between seronegative and seropositive patients. RESULT(S): Of 1,000 patients enrolled, 995 completed serologic screening and 968 underwent oocyte retrieval. Eighteen patients screened positive for both tTG and EMA (1.8%) and 10 additional patients (1.0%) screened positive for one of the two antibodies. The number of mature oocytes retrieved, fertilization rates, and blastulation rates were equivalent between seronegative and seropositive patients. There were 987 patients who completed the questionnaire (98.7%), and 84 reported being gluten free (8.5%). Those who reported being gluten free were no more likely to be antibody positive than the general population. Furthermore, a low-gluten diet was not associated with markers of ovarian reserve, oocytes retrieved, fertilization, blastulation, sustained implantation and pregnancy loss rates. CONCLUSION(S): The prevalence of seropositive celiac disease was consistent with that of the general population (2.8%). Patients who were seropositive for celiac disease-related antibodies had outcomes equivalent to seronegative patients, and patients with a gluten-free diet did not have improved outcomes.

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Published In

Fertil Steril

DOI

EISSN

1556-5653

Publication Date

August 2018

Volume

110

Issue

3

Start / End Page

437 / 442

Location

United States

Related Subject Headings

  • Transglutaminases
  • Surveys and Questionnaires
  • Reproduction
  • Protein Glutamine gamma Glutamyltransferase 2
  • Prospective Studies
  • Prevalence
  • Pregnancy Rate
  • Pregnancy
  • Oocyte Retrieval
  • Obstetrics & Reproductive Medicine
 

Citation

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Juneau, C. R., Franasiak, J. M., Goodman, L. R., Marin, D., Scott, K., Morin, S. J., … Scott, R. T. (2018). Celiac disease is not more prevalent in patients undergoing in vitro fertilization and does not affect reproductive outcomes with or without treatment: a large prospective cohort study. Fertil Steril, 110(3), 437–442. https://doi.org/10.1016/j.fertnstert.2018.03.030
Juneau, Caroline R., Jason M. Franasiak, Linnea R. Goodman, Diego Marin, Katherine Scott, Scott J. Morin, Shelby A. Neal, Jeffrey E. Juneau, and Richard T. Scott. “Celiac disease is not more prevalent in patients undergoing in vitro fertilization and does not affect reproductive outcomes with or without treatment: a large prospective cohort study.Fertil Steril 110, no. 3 (August 2018): 437–42. https://doi.org/10.1016/j.fertnstert.2018.03.030.
Juneau, Caroline R., et al. “Celiac disease is not more prevalent in patients undergoing in vitro fertilization and does not affect reproductive outcomes with or without treatment: a large prospective cohort study.Fertil Steril, vol. 110, no. 3, Aug. 2018, pp. 437–42. Pubmed, doi:10.1016/j.fertnstert.2018.03.030.
Juneau CR, Franasiak JM, Goodman LR, Marin D, Scott K, Morin SJ, Neal SA, Juneau JE, Scott RT. Celiac disease is not more prevalent in patients undergoing in vitro fertilization and does not affect reproductive outcomes with or without treatment: a large prospective cohort study. Fertil Steril. 2018 Aug;110(3):437–442.
Journal cover image

Published In

Fertil Steril

DOI

EISSN

1556-5653

Publication Date

August 2018

Volume

110

Issue

3

Start / End Page

437 / 442

Location

United States

Related Subject Headings

  • Transglutaminases
  • Surveys and Questionnaires
  • Reproduction
  • Protein Glutamine gamma Glutamyltransferase 2
  • Prospective Studies
  • Prevalence
  • Pregnancy Rate
  • Pregnancy
  • Oocyte Retrieval
  • Obstetrics & Reproductive Medicine