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Comorbidity Profiles and Lung Cancer Screening among Older Adults: U.S. Behavioral Risk Factor Surveillance System 2017-2019.

Publication ,  Journal Article
Advani, S; Zhang, D; Tammemagi, M; Akinyemiju, T; Gould, MK; Silvestri, GA; Braithwaite, D
Published in: Ann Am Thorac Soc
November 2021

Rationale: Although lung cancer screening (LCS) with low-dose computed tomography (LDCT) is now recommended for those meeting standard risk factor-based eligibility criteria, the role of comorbidity in the uptake of LCS with LDCT in an older real-world U.S. population is not well established. Objectives: To examine the relationships between comorbidity, functional status, and LCS utilization in the United States. Methods: Using population-based data from the 2017-2019 Behavioral Risk Factor Surveillance System, we examined the association of comorbid conditions and functional limitations regarding activities of daily living with LCS utilization among participants that met the LCS criteria based on the U.S. Preventive Service Taskforce guidelines. We employed multivariable weighted logistic regression models to evaluate these associations, both overall and within subgroups defined by age (<65 yr vs. ⩾65 yr), sex, and smoking history. Results: Of 11,214 participants who met the eligibility criteria for LCS, 1,731 (16%) underwent LCS with LDCT. The majority were White (90%), male (55%), former smokers (52%), and living with at least one chronic comorbid condition (77%). More than 28% had three or more comorbid conditions, and approximately 40% of participants reported having some form of functional limitations. In the multivariable models, the likelihood of undergoing LCS with LDCT within the past year was positively associated with higher amount of comorbidity (⩾5 vs. 0: adjusted odds ratio, 2.34; 95% confidence interval [CI], 1.22-4.48) but not with functional limitations (⩾3 vs. 0: adjusted odds ratio, 1.00; 95% CI, 0.66-1.50). Conclusions: The presence of comorbid conditions is associated with a higher likelihood of undergoing LCS with LDCT. Because poor health status may diminish the benefits of screening, future research is needed to precisely characterize the health status of LCS-eligible individuals.

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Published In

Ann Am Thorac Soc

DOI

EISSN

2325-6621

Publication Date

November 2021

Volume

18

Issue

11

Start / End Page

1886 / 1893

Location

United States

Related Subject Headings

  • United States
  • Mass Screening
  • Male
  • Lung Neoplasms
  • Humans
  • Early Detection of Cancer
  • Comorbidity
  • Behavioral Risk Factor Surveillance System
  • Aged
  • Activities of Daily Living
 

Citation

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Advani, S., Zhang, D., Tammemagi, M., Akinyemiju, T., Gould, M. K., Silvestri, G. A., & Braithwaite, D. (2021). Comorbidity Profiles and Lung Cancer Screening among Older Adults: U.S. Behavioral Risk Factor Surveillance System 2017-2019. Ann Am Thorac Soc, 18(11), 1886–1893. https://doi.org/10.1513/AnnalsATS.202010-1276OC
Advani, Shailesh, Dongyu Zhang, Martin Tammemagi, Tomi Akinyemiju, Michael K. Gould, Gerard A. Silvestri, and Dejana Braithwaite. “Comorbidity Profiles and Lung Cancer Screening among Older Adults: U.S. Behavioral Risk Factor Surveillance System 2017-2019.Ann Am Thorac Soc 18, no. 11 (November 2021): 1886–93. https://doi.org/10.1513/AnnalsATS.202010-1276OC.
Advani S, Zhang D, Tammemagi M, Akinyemiju T, Gould MK, Silvestri GA, et al. Comorbidity Profiles and Lung Cancer Screening among Older Adults: U.S. Behavioral Risk Factor Surveillance System 2017-2019. Ann Am Thorac Soc. 2021 Nov;18(11):1886–93.
Advani, Shailesh, et al. “Comorbidity Profiles and Lung Cancer Screening among Older Adults: U.S. Behavioral Risk Factor Surveillance System 2017-2019.Ann Am Thorac Soc, vol. 18, no. 11, Nov. 2021, pp. 1886–93. Pubmed, doi:10.1513/AnnalsATS.202010-1276OC.
Advani S, Zhang D, Tammemagi M, Akinyemiju T, Gould MK, Silvestri GA, Braithwaite D. Comorbidity Profiles and Lung Cancer Screening among Older Adults: U.S. Behavioral Risk Factor Surveillance System 2017-2019. Ann Am Thorac Soc. 2021 Nov;18(11):1886–1893.

Published In

Ann Am Thorac Soc

DOI

EISSN

2325-6621

Publication Date

November 2021

Volume

18

Issue

11

Start / End Page

1886 / 1893

Location

United States

Related Subject Headings

  • United States
  • Mass Screening
  • Male
  • Lung Neoplasms
  • Humans
  • Early Detection of Cancer
  • Comorbidity
  • Behavioral Risk Factor Surveillance System
  • Aged
  • Activities of Daily Living