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Biofabrication of tissue engineering vascular systems.

Publication ,  Journal Article
Zhang, Q; Bosch-Rué, È; Pérez, RA; Truskey, GA
Published in: APL bioengineering
June 2021

Cardiovascular disease (CVD) is the leading cause of death among persons aged 65 and older in the United States and many other developed countries. Tissue engineered vascular systems (TEVS) can serve as grafts for CVD treatment and be used as in vitro model systems to examine the role of various genetic factors during the CVD progressions. Current focus in the field is to fabricate TEVS that more closely resembles the mechanical properties and extracellular matrix environment of native vessels, which depends heavily on the advance in biofabrication techniques and discovery of novel biomaterials. In this review, we outline the mechanical and biological design requirements of TEVS and explore the history and recent advances in biofabrication methods and biomaterials for tissue engineered blood vessels and microvascular systems with special focus on in vitro applications. In vitro applications of TEVS for disease modeling are discussed.

Duke Scholars

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Published In

APL bioengineering

DOI

EISSN

2473-2877

ISSN

2473-2877

Publication Date

June 2021

Volume

5

Issue

2

Start / End Page

021507

Related Subject Headings

  • 4003 Biomedical engineering
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zhang, Q., Bosch-Rué, È., Pérez, R. A., & Truskey, G. A. (2021). Biofabrication of tissue engineering vascular systems. APL Bioengineering, 5(2), 021507. https://doi.org/10.1063/5.0039628
Zhang, Qiao, Èlia Bosch-Rué, Román A. Pérez, and George A. Truskey. “Biofabrication of tissue engineering vascular systems.APL Bioengineering 5, no. 2 (June 2021): 021507. https://doi.org/10.1063/5.0039628.
Zhang Q, Bosch-Rué È, Pérez RA, Truskey GA. Biofabrication of tissue engineering vascular systems. APL bioengineering. 2021 Jun;5(2):021507.
Zhang, Qiao, et al. “Biofabrication of tissue engineering vascular systems.APL Bioengineering, vol. 5, no. 2, June 2021, p. 021507. Epmc, doi:10.1063/5.0039628.
Zhang Q, Bosch-Rué È, Pérez RA, Truskey GA. Biofabrication of tissue engineering vascular systems. APL bioengineering. 2021 Jun;5(2):021507.

Published In

APL bioengineering

DOI

EISSN

2473-2877

ISSN

2473-2877

Publication Date

June 2021

Volume

5

Issue

2

Start / End Page

021507

Related Subject Headings

  • 4003 Biomedical engineering