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Antifungals in Clinical Use and the Pipeline.

Publication ,  Journal Article
Johnson, MD
Published in: Infect Dis Clin North Am
June 2021

Over the past 15 years, there has been an increase in the development and utilization of newer antifungal agents. The ideal antifungal, however, in regard to spectrum of activity, pharmacokinetic/pharmacodynamic properties, development of resistance, safety, and drug interaction profile remains elusive. This article reviews pharmacologic aspects of Food and Drug Administration-approved polyenes, flucytosine, azoles, and echinocandins as well as promising pipeline antifungal agents. Unique properties of these newer agents are highlighted. The clinical role of established and investigational antifungal agents as treatment and/or prevention of invasive fungal infections is discussed.

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Published In

Infect Dis Clin North Am

DOI

EISSN

1557-9824

Publication Date

June 2021

Volume

35

Issue

2

Start / End Page

341 / 371

Location

United States

Related Subject Headings

  • United States
  • Polyenes
  • Mycoses
  • Microbiology
  • Humans
  • Flucytosine
  • Echinocandins
  • Drugs, Investigational
  • Azoles
  • Antifungal Agents
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Johnson, M. D. (2021). Antifungals in Clinical Use and the Pipeline. Infect Dis Clin North Am, 35(2), 341–371. https://doi.org/10.1016/j.idc.2021.03.005
Johnson, Melissa D. “Antifungals in Clinical Use and the Pipeline.Infect Dis Clin North Am 35, no. 2 (June 2021): 341–71. https://doi.org/10.1016/j.idc.2021.03.005.
Johnson MD. Antifungals in Clinical Use and the Pipeline. Infect Dis Clin North Am. 2021 Jun;35(2):341–71.
Johnson, Melissa D. “Antifungals in Clinical Use and the Pipeline.Infect Dis Clin North Am, vol. 35, no. 2, June 2021, pp. 341–71. Pubmed, doi:10.1016/j.idc.2021.03.005.
Johnson MD. Antifungals in Clinical Use and the Pipeline. Infect Dis Clin North Am. 2021 Jun;35(2):341–371.
Journal cover image

Published In

Infect Dis Clin North Am

DOI

EISSN

1557-9824

Publication Date

June 2021

Volume

35

Issue

2

Start / End Page

341 / 371

Location

United States

Related Subject Headings

  • United States
  • Polyenes
  • Mycoses
  • Microbiology
  • Humans
  • Flucytosine
  • Echinocandins
  • Drugs, Investigational
  • Azoles
  • Antifungal Agents