
Antifungals in Clinical Use and the Pipeline.
Publication
, Journal Article
Johnson, MD
Published in: Infect Dis Clin North Am
June 2021
Over the past 15 years, there has been an increase in the development and utilization of newer antifungal agents. The ideal antifungal, however, in regard to spectrum of activity, pharmacokinetic/pharmacodynamic properties, development of resistance, safety, and drug interaction profile remains elusive. This article reviews pharmacologic aspects of Food and Drug Administration-approved polyenes, flucytosine, azoles, and echinocandins as well as promising pipeline antifungal agents. Unique properties of these newer agents are highlighted. The clinical role of established and investigational antifungal agents as treatment and/or prevention of invasive fungal infections is discussed.
Duke Scholars
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Published In
Infect Dis Clin North Am
DOI
EISSN
1557-9824
Publication Date
June 2021
Volume
35
Issue
2
Start / End Page
341 / 371
Location
United States
Related Subject Headings
- United States
- Polyenes
- Mycoses
- Microbiology
- Humans
- Flucytosine
- Echinocandins
- Drugs, Investigational
- Azoles
- Antifungal Agents
Citation
APA
Chicago
ICMJE
MLA
NLM
Johnson, M. D. (2021). Antifungals in Clinical Use and the Pipeline. Infect Dis Clin North Am, 35(2), 341–371. https://doi.org/10.1016/j.idc.2021.03.005
Johnson, Melissa D. “Antifungals in Clinical Use and the Pipeline.” Infect Dis Clin North Am 35, no. 2 (June 2021): 341–71. https://doi.org/10.1016/j.idc.2021.03.005.
Johnson MD. Antifungals in Clinical Use and the Pipeline. Infect Dis Clin North Am. 2021 Jun;35(2):341–71.
Johnson, Melissa D. “Antifungals in Clinical Use and the Pipeline.” Infect Dis Clin North Am, vol. 35, no. 2, June 2021, pp. 341–71. Pubmed, doi:10.1016/j.idc.2021.03.005.
Johnson MD. Antifungals in Clinical Use and the Pipeline. Infect Dis Clin North Am. 2021 Jun;35(2):341–371.

Published In
Infect Dis Clin North Am
DOI
EISSN
1557-9824
Publication Date
June 2021
Volume
35
Issue
2
Start / End Page
341 / 371
Location
United States
Related Subject Headings
- United States
- Polyenes
- Mycoses
- Microbiology
- Humans
- Flucytosine
- Echinocandins
- Drugs, Investigational
- Azoles
- Antifungal Agents