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Effects of Low-Frequency Repetitive Transcranial Magnetic Stimulation on Language Recovery in Poststroke Survivors With Aphasia: An Updated Meta-analysis.

Publication ,  Journal Article
Hong, Z; Zheng, H; Luo, J; Yin, M; Ai, Y; Deng, B; Feng, W; Hu, X
Published in: Neurorehabilitation and neural repair
August 2021

The effects of low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) on treating poststroke aphasia (PSA) remain inconclusive. We aimed to evaluate the efficacy and safety of LF-rTMS on language function poststroke and determine potential factors that may affect treatment effects. Electronic databases, including MEDLINE, EMBASE, and Cochrane Library were searched to identify relevant randomized controlled trials (RCTs) concerning the effects of LF-rTMS on language performance poststroke. We adopted fixed- and random-effects models to estimate intervention effects, which were represented by the Hedges' g and 95% CIs. Subgroup analyses regarding several factors potentially influencing the effects of LF-rTMS on language recovery were also conducted. A total of 14 RCTs involving 374 participants were included in the meta-analysis. The pooled analysis showed the positive and significant effects of LF-rTMS on language function, both short-term (Hedges' g = 0.65; P < .05) and long-term (Hedges' g = 0.46; P < .05). Subgroup analyses demonstrated that LF-rTMS for 20 minutes per day over 10 days yielded the largest effect size (Hedges' g = 1.02; P < .05) and that LF-rTMS significantly improved language performance in the chronic stage after stroke (Hedges' g = 0.55; P < .05). Patients with different native languages might have diverse responses to LF-rTMS treatment efficacy. Additionally, there were significant improvements in language subtests, including naming, repetition, comprehension, and writing. Overall, this updated meta-analysis demonstrated that LF-rTMS has significant positive effects on PSA, with moderate treatment effects. It provides additional evidence to support LF-rTMS as a promising complementary therapy to promote language recovery in PSA.

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Published In

Neurorehabilitation and neural repair

DOI

EISSN

1552-6844

ISSN

1545-9683

Publication Date

August 2021

Volume

35

Issue

8

Start / End Page

680 / 691

Related Subject Headings

  • Treatment Outcome
  • Transcranial Magnetic Stimulation
  • Stroke Rehabilitation
  • Stroke
  • Rehabilitation
  • Language
  • Humans
  • Aphasia
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Hong, Z., Zheng, H., Luo, J., Yin, M., Ai, Y., Deng, B., … Hu, X. (2021). Effects of Low-Frequency Repetitive Transcranial Magnetic Stimulation on Language Recovery in Poststroke Survivors With Aphasia: An Updated Meta-analysis. Neurorehabilitation and Neural Repair, 35(8), 680–691. https://doi.org/10.1177/15459683211011230
Hong, Zhongqiu, Haiqing Zheng, Jing Luo, Mingyu Yin, Yinan Ai, Baomei Deng, Wuwei Feng, and Xiquan Hu. “Effects of Low-Frequency Repetitive Transcranial Magnetic Stimulation on Language Recovery in Poststroke Survivors With Aphasia: An Updated Meta-analysis.Neurorehabilitation and Neural Repair 35, no. 8 (August 2021): 680–91. https://doi.org/10.1177/15459683211011230.
Hong Z, Zheng H, Luo J, Yin M, Ai Y, Deng B, et al. Effects of Low-Frequency Repetitive Transcranial Magnetic Stimulation on Language Recovery in Poststroke Survivors With Aphasia: An Updated Meta-analysis. Neurorehabilitation and neural repair. 2021 Aug;35(8):680–91.
Hong, Zhongqiu, et al. “Effects of Low-Frequency Repetitive Transcranial Magnetic Stimulation on Language Recovery in Poststroke Survivors With Aphasia: An Updated Meta-analysis.Neurorehabilitation and Neural Repair, vol. 35, no. 8, Aug. 2021, pp. 680–91. Epmc, doi:10.1177/15459683211011230.
Hong Z, Zheng H, Luo J, Yin M, Ai Y, Deng B, Feng W, Hu X. Effects of Low-Frequency Repetitive Transcranial Magnetic Stimulation on Language Recovery in Poststroke Survivors With Aphasia: An Updated Meta-analysis. Neurorehabilitation and neural repair. 2021 Aug;35(8):680–691.
Journal cover image

Published In

Neurorehabilitation and neural repair

DOI

EISSN

1552-6844

ISSN

1545-9683

Publication Date

August 2021

Volume

35

Issue

8

Start / End Page

680 / 691

Related Subject Headings

  • Treatment Outcome
  • Transcranial Magnetic Stimulation
  • Stroke Rehabilitation
  • Stroke
  • Rehabilitation
  • Language
  • Humans
  • Aphasia
  • 3209 Neurosciences
  • 1702 Cognitive Sciences