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Diagnosis, Education, and Care of Patients with APOL1-Associated Nephropathy: A Delphi Consensus and Systematic Review.

Publication ,  Journal Article
Freedman, BI; Burke, W; Divers, J; Eberhard, L; Gadegbeku, CA; Gbadegesin, R; Hall, ME; Jones-Smith, T; Knight, R; Kopp, JB; Kovesdy, CP ...
Published in: Journal of the American Society of Nephrology : JASN
July 2021

APOL1 variants contribute to the markedly higher incidence of ESKD in Blacks compared with Whites. Genetic testing for these variants in patients with African ancestry who have nephropathy is uncommon, and no specific treatment or management protocol for APOL1-associated nephropathy currently exists.A multidisciplinary, racially diverse group of 14 experts and patient advocates participated in a Delphi consensus process to establish practical guidance for clinicians caring for patients who may have APOL1-associated nephropathy. Consensus group members took part in three anonymous voting rounds to develop consensus statements relating to the following: (1) counseling, genotyping, and diagnosis; (2) disease awareness and education; and (3) a vision for management of APOL1-associated nephropathy in a future when treatment is available. A systematic literature search of the MEDLINE and Embase databases was conducted to identify relevant evidence published from January 1, 2009 to July 14, 2020.The consensus group agreed on 55 consensus statements covering such topics as demographic and clinical factors that suggest a patient has APOL1-associated nephropathy, as well as key considerations for counseling, testing, and diagnosis in current clinical practice. They achieved consensus on the need to increase awareness among key stakeholders of racial health disparities in kidney disease and of APOL1-associated nephropathy and on features of a successful education program to raise awareness among the patient community. The group also highlighted the unmet need for a specific treatment and agreed on best practice for management of these patients should a treatment become available.A multidisciplinary group of experts and patient advocates defined consensus-based guidance on the care of patients who may have APOL1-associated nephropathy.

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Published In

Journal of the American Society of Nephrology : JASN

DOI

EISSN

1533-3450

ISSN

1046-6673

Publication Date

July 2021

Volume

32

Issue

7

Start / End Page

1765 / 1778

Related Subject Headings

  • Urology & Nephrology
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Freedman, B. I., Burke, W., Divers, J., Eberhard, L., Gadegbeku, C. A., Gbadegesin, R., … Blacksher, E. (2021). Diagnosis, Education, and Care of Patients with APOL1-Associated Nephropathy: A Delphi Consensus and Systematic Review. Journal of the American Society of Nephrology : JASN, 32(7), 1765–1778. https://doi.org/10.1681/asn.2020101399
Freedman, Barry I., Wylie Burke, Jasmin Divers, Lucy Eberhard, Crystal A. Gadegbeku, Rasheed Gbadegesin, Michael E. Hall, et al. “Diagnosis, Education, and Care of Patients with APOL1-Associated Nephropathy: A Delphi Consensus and Systematic Review.Journal of the American Society of Nephrology : JASN 32, no. 7 (July 2021): 1765–78. https://doi.org/10.1681/asn.2020101399.
Freedman BI, Burke W, Divers J, Eberhard L, Gadegbeku CA, Gbadegesin R, et al. Diagnosis, Education, and Care of Patients with APOL1-Associated Nephropathy: A Delphi Consensus and Systematic Review. Journal of the American Society of Nephrology : JASN. 2021 Jul;32(7):1765–78.
Freedman, Barry I., et al. “Diagnosis, Education, and Care of Patients with APOL1-Associated Nephropathy: A Delphi Consensus and Systematic Review.Journal of the American Society of Nephrology : JASN, vol. 32, no. 7, July 2021, pp. 1765–78. Epmc, doi:10.1681/asn.2020101399.
Freedman BI, Burke W, Divers J, Eberhard L, Gadegbeku CA, Gbadegesin R, Hall ME, Jones-Smith T, Knight R, Kopp JB, Kovesdy CP, Norris KC, Olabisi OA, Roberts GV, Sedor JR, Blacksher E. Diagnosis, Education, and Care of Patients with APOL1-Associated Nephropathy: A Delphi Consensus and Systematic Review. Journal of the American Society of Nephrology : JASN. 2021 Jul;32(7):1765–1778.

Published In

Journal of the American Society of Nephrology : JASN

DOI

EISSN

1533-3450

ISSN

1046-6673

Publication Date

July 2021

Volume

32

Issue

7

Start / End Page

1765 / 1778

Related Subject Headings

  • Urology & Nephrology
  • 3202 Clinical sciences
  • 1103 Clinical Sciences