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Multifocal mantle cell lymphoma in situ in the setting of a composite lymphoma.

Publication ,  Journal Article
Sloan, C; Xiong, Q-B; Crivaro, A; Steinman, S; Bagg, A
Published in: Am J Clin Pathol
February 2015

OBJECTIVES: Mantle cell lymphoma in situ (MCLIS) consists of immunophenotypically defined but histologically inapparent neoplastic cells restricted to narrow mantle zones, without expansion or invasion beyond the mantle zone. We report a unique case of MCLIS associated with a much more manifest nodal marginal zone lymphoma (MZL) in an inguinal lymph node, porta hepatis lymph node, and bone marrow. METHODS: Biopsies from all three locations were evaluated using standard H&E-stained sections, immunohistochemistry, flow cytometry, metaphase cytogenetics, and/or fluorescence in situ hybridization (FISH). RESULTS: This case is unique for three reasons. First, the histologically covert mantle cell lymphoma was multifocal, detected in all three locations using one or more of flow cytometry, immunohistochemistry, cytogenetics, and FISH. Second, the MCLIS was always accompanied by a more histologically dominant MZL. Third, where evaluable, it did not grow in an appreciable mantle zone distribution, presumably due to destruction of the normal nodal architecture by the neoplastic MZL cells and the resulting absence of recognizable follicles and mantle zones. CONCLUSIONS: This unique case provides new insight into the pathogenesis of MCLIS.

Duke Scholars

Published In

Am J Clin Pathol

DOI

EISSN

1943-7722

Publication Date

February 2015

Volume

143

Issue

2

Start / End Page

274 / 282

Location

England

Related Subject Headings

  • Polymerase Chain Reaction
  • Pathology
  • Middle Aged
  • Male
  • Lymphoma, Mantle-Cell
  • Lymphoma, B-Cell, Marginal Zone
  • Lymph Nodes
  • In Situ Hybridization, Fluorescence
  • Immunophenotyping
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Sloan, C., Xiong, Q.-B., Crivaro, A., Steinman, S., & Bagg, A. (2015). Multifocal mantle cell lymphoma in situ in the setting of a composite lymphoma. Am J Clin Pathol, 143(2), 274–282. https://doi.org/10.1309/AJCP06VIKFMTRCXD
Sloan, Caroline, Qun-Bin Xiong, Anne Crivaro, Sharon Steinman, and Adam Bagg. “Multifocal mantle cell lymphoma in situ in the setting of a composite lymphoma.Am J Clin Pathol 143, no. 2 (February 2015): 274–82. https://doi.org/10.1309/AJCP06VIKFMTRCXD.
Sloan C, Xiong Q-B, Crivaro A, Steinman S, Bagg A. Multifocal mantle cell lymphoma in situ in the setting of a composite lymphoma. Am J Clin Pathol. 2015 Feb;143(2):274–82.
Sloan, Caroline, et al. “Multifocal mantle cell lymphoma in situ in the setting of a composite lymphoma.Am J Clin Pathol, vol. 143, no. 2, Feb. 2015, pp. 274–82. Pubmed, doi:10.1309/AJCP06VIKFMTRCXD.
Sloan C, Xiong Q-B, Crivaro A, Steinman S, Bagg A. Multifocal mantle cell lymphoma in situ in the setting of a composite lymphoma. Am J Clin Pathol. 2015 Feb;143(2):274–282.
Journal cover image

Published In

Am J Clin Pathol

DOI

EISSN

1943-7722

Publication Date

February 2015

Volume

143

Issue

2

Start / End Page

274 / 282

Location

England

Related Subject Headings

  • Polymerase Chain Reaction
  • Pathology
  • Middle Aged
  • Male
  • Lymphoma, Mantle-Cell
  • Lymphoma, B-Cell, Marginal Zone
  • Lymph Nodes
  • In Situ Hybridization, Fluorescence
  • Immunophenotyping
  • Humans