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Differentiation of fetal sertoli cells in the adult testis.

Publication ,  Journal Article
Yokonishi, T; Capel, B
Published in: Reproduction
July 8, 2021

Sertoli cells proliferate and construct seminiferous tubules during fetal life, then undergo differentiation and maturation in the prepubertal testes. In the adult testes, mature Sertoli cells maintain spermatogonia and support spermatogenesis during the entire lifetime. Although Sertoli-like cells have been derived from iPS cells, they tend to remain immature. To investigate whether Sertoli cells can spontaneously acquire the ability to support spermatogenesis when transferred into the adult testis, we transplanted mouse fetal testicular cells into a Sertoli-depleted adult testis. We found that donor E12.5, E14.5 and E16.5 Sertoli cells colonized adult seminiferous tubules and supported host spermatogenesis 2 months after transplantation, demonstrating that immature fetal Sertoli cells can undergo sufficient maturation in the adult testis to become functional. This technique will be useful to analyze the developmental process of Sertoli cell maturation and to investigate the potential of iPS-derived Sertoli cells to colonize, undergo maturation, and support spermatogenesis within the testis environment.

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Published In

Reproduction

DOI

EISSN

1741-7899

Publication Date

July 8, 2021

Volume

162

Issue

2

Start / End Page

141 / 147

Location

England

Related Subject Headings

  • Testis
  • Spermatogenesis
  • Sexual Maturation
  • Sertoli Cells
  • Seminiferous Tubules
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Mice
  • Male
  • Fetus
 

Citation

APA
Chicago
ICMJE
MLA
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Yokonishi, T., & Capel, B. (2021). Differentiation of fetal sertoli cells in the adult testis. Reproduction, 162(2), 141–147. https://doi.org/10.1530/REP-21-0106
Yokonishi, Tetsuhiro, and Blanche Capel. “Differentiation of fetal sertoli cells in the adult testis.Reproduction 162, no. 2 (July 8, 2021): 141–47. https://doi.org/10.1530/REP-21-0106.
Yokonishi T, Capel B. Differentiation of fetal sertoli cells in the adult testis. Reproduction. 2021 Jul 8;162(2):141–7.
Yokonishi, Tetsuhiro, and Blanche Capel. “Differentiation of fetal sertoli cells in the adult testis.Reproduction, vol. 162, no. 2, July 2021, pp. 141–47. Pubmed, doi:10.1530/REP-21-0106.
Yokonishi T, Capel B. Differentiation of fetal sertoli cells in the adult testis. Reproduction. 2021 Jul 8;162(2):141–147.

Published In

Reproduction

DOI

EISSN

1741-7899

Publication Date

July 8, 2021

Volume

162

Issue

2

Start / End Page

141 / 147

Location

England

Related Subject Headings

  • Testis
  • Spermatogenesis
  • Sexual Maturation
  • Sertoli Cells
  • Seminiferous Tubules
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Mice
  • Male
  • Fetus