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Targeted vs. systematic early antiviral treatment against A(H1N1)v influenza with neuraminidase inhibitors in patients with influenza-like symptoms: clinical and economic impact.

Publication ,  Journal Article
Deuffic-Burban, S; Lenne, X; Dervaux, B; Julien Poissy, ; Lemaire, X; Sloan, C; Carrat, F; Desenclos, J-C; Delfraissy, J-F; Yazdanpanah, Y
Published in: PLoS Curr
October 26, 2009

Capitalizing on available data, we used a decision model to estimate the clinical and economic outcomes associated with early initiation of treatment with neuraminidase inhibitors in all patients with influenza-like illnesses ( ILI ) (systematic strategy) vs. only those at high risk of complications (targeted strategy). Systematic treatment of ILI during an A(H1N1)v influenza epidemic wave is both effective and cost-effective. Patients who present to care with ILI during an A(H1N1)v influenza epidemic wave should initiate treatment with neuraminidase inhibitors, regardless of risk status. Administering neuraminidase inhibitors between epidemic waves, when the probability of influenza is low, is less effective and cost-effective.

Duke Scholars

Published In

PLoS Curr

DOI

EISSN

2157-3999

Publication Date

October 26, 2009

Volume

1

Start / End Page

RRN1121

Location

United States

Related Subject Headings

  • 3104 Evolutionary biology
  • 0603 Evolutionary Biology
 

Citation

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Deuffic-Burban, S., Lenne, X., Dervaux, B., Julien Poissy, ., Lemaire, X., Sloan, C., … Yazdanpanah, Y. (2009). Targeted vs. systematic early antiviral treatment against A(H1N1)v influenza with neuraminidase inhibitors in patients with influenza-like symptoms: clinical and economic impact. PLoS Curr, 1, RRN1121. https://doi.org/10.1371/currents.rrn1121
Deuffic-Burban, Sylvie, Xavier Lenne, Benoit Dervaux, Benoit Julien Poissy, Xavier Lemaire, Caroline Sloan, Fabrice Carrat, Jean-Claude Desenclos, Jean-Francois Delfraissy, and Yazdan Yazdanpanah. “Targeted vs. systematic early antiviral treatment against A(H1N1)v influenza with neuraminidase inhibitors in patients with influenza-like symptoms: clinical and economic impact.PLoS Curr 1 (October 26, 2009): RRN1121. https://doi.org/10.1371/currents.rrn1121.
Deuffic-Burban S, Lenne X, Dervaux B, Julien Poissy, Lemaire X, Sloan C, Carrat F, Desenclos J-C, Delfraissy J-F, Yazdanpanah Y. Targeted vs. systematic early antiviral treatment against A(H1N1)v influenza with neuraminidase inhibitors in patients with influenza-like symptoms: clinical and economic impact. PLoS Curr. 2009 Oct 26;1:RRN1121.

Published In

PLoS Curr

DOI

EISSN

2157-3999

Publication Date

October 26, 2009

Volume

1

Start / End Page

RRN1121

Location

United States

Related Subject Headings

  • 3104 Evolutionary biology
  • 0603 Evolutionary Biology