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Continuous Fabrication of Antimicrobial Nanofiber Mats Using Post-Electrospinning Functionalization for Roll-to-Roll Scale-Up

Publication ,  Journal Article
Chen, K; Nikam, SP; Zander, ZK; Hsu, YH; Dreger, NZ; Cakmak, M; Becker, ML
Published in: ACS Applied Polymer Materials
February 14, 2020

The facile fabrication of antimicrobial fiber mats with surface-attached quaternary ammonium compounds (QACs) as the contact-killing antimicrobials was demonstrated. The entire process was designed to be scaled up to a continuous roll-to-roll (R2R) process using a customized R2R manufacturing platform that combines a multinozzle electrospinning technique to generate homogeneous fiber mats and a wet chemical dipping cycle with UV treatment for post-functionalization. A thiol-ene "click"reaction was used to chemically tether a QAC thiol (QAC-SH) on the surface of electrospun fibers containing an alkene functional handle (allyl-TPU). The control of the electrospinning conditions and fiber morphology was investigated by changing the solution concentrations and the tip-to-collector distance (TD). A critical solution concentration correlated to the onset of chain entanglement was necessary to obtain uniform fiber morphology. Surface functionalization of the covalently attached QAC-SH was quantified by fluorescence spectroscopy and X-ray photoelectron spectroscopy (XPS) following the "click"reactions. Antimicrobial assays demonstrated the rapid (>30% in 15 min) and sustained (1-3-log reduction in 4 and 24 h) contact-killing efficacies of QAC-SH-functionalized fiber mats against both Gram-positive (S. aureus) and Gram-negative (E. coli) bacteria, further demonstrating the feasibility of implementing the post-functionalization process in a continuous R2R manner.

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Published In

ACS Applied Polymer Materials

DOI

EISSN

2637-6105

Publication Date

February 14, 2020

Volume

2

Issue

2

Start / End Page

304 / 316

Related Subject Headings

  • 4016 Materials engineering
  • 3403 Macromolecular and materials chemistry
 

Citation

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Chicago
ICMJE
MLA
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Chen, K., Nikam, S. P., Zander, Z. K., Hsu, Y. H., Dreger, N. Z., Cakmak, M., & Becker, M. L. (2020). Continuous Fabrication of Antimicrobial Nanofiber Mats Using Post-Electrospinning Functionalization for Roll-to-Roll Scale-Up. ACS Applied Polymer Materials, 2(2), 304–316. https://doi.org/10.1021/acsapm.9b00798
Chen, K., S. P. Nikam, Z. K. Zander, Y. H. Hsu, N. Z. Dreger, M. Cakmak, and M. L. Becker. “Continuous Fabrication of Antimicrobial Nanofiber Mats Using Post-Electrospinning Functionalization for Roll-to-Roll Scale-Up.” ACS Applied Polymer Materials 2, no. 2 (February 14, 2020): 304–16. https://doi.org/10.1021/acsapm.9b00798.
Chen K, Nikam SP, Zander ZK, Hsu YH, Dreger NZ, Cakmak M, et al. Continuous Fabrication of Antimicrobial Nanofiber Mats Using Post-Electrospinning Functionalization for Roll-to-Roll Scale-Up. ACS Applied Polymer Materials. 2020 Feb 14;2(2):304–16.
Chen, K., et al. “Continuous Fabrication of Antimicrobial Nanofiber Mats Using Post-Electrospinning Functionalization for Roll-to-Roll Scale-Up.” ACS Applied Polymer Materials, vol. 2, no. 2, Feb. 2020, pp. 304–16. Scopus, doi:10.1021/acsapm.9b00798.
Chen K, Nikam SP, Zander ZK, Hsu YH, Dreger NZ, Cakmak M, Becker ML. Continuous Fabrication of Antimicrobial Nanofiber Mats Using Post-Electrospinning Functionalization for Roll-to-Roll Scale-Up. ACS Applied Polymer Materials. 2020 Feb 14;2(2):304–316.

Published In

ACS Applied Polymer Materials

DOI

EISSN

2637-6105

Publication Date

February 14, 2020

Volume

2

Issue

2

Start / End Page

304 / 316

Related Subject Headings

  • 4016 Materials engineering
  • 3403 Macromolecular and materials chemistry