Skip to main content

ALSUntangled #61: melatonin.

Publication ,  Journal Article
ALSUNTANGLED GROUP,
Published in: Amyotroph Lateral Scler Frontotemporal Degener
February 2022

ALSUntangled reviews alternative and off-label treatments for people with amyotrophic lateral sclerosis (ALS). Here we review melatonin. We show that it has plausible mechanisms, some positive (and some negative) pre-clinical studies, two cases in which cocktails of supplements including melatonin were associated with recovery of lost motor function, and a very small, flawed retrospective study suggesting that patients in the PRO-ACT database who reported taking melatonin progressed more slowly and lived longer compared to those who were not taking it. Melatonin appears safe, but an optimal dose and route of administration for ALS have not been determined. Based on all this, we support a pilot trial of melatonin in people with ALS but we cannot yet recommend it as a treatment.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Amyotroph Lateral Scler Frontotemporal Degener

DOI

EISSN

2167-9223

Publication Date

February 2022

Volume

23

Issue

1-2

Start / End Page

157 / 160

Location

England

Related Subject Headings

  • Retrospective Studies
  • Melatonin
  • Humans
  • Amyotrophic Lateral Sclerosis
  • 3209 Neurosciences
  • 1109 Neurosciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
ALSUNTANGLED GROUP, . (2022). ALSUntangled #61: melatonin. Amyotroph Lateral Scler Frontotemporal Degener, 23(1–2), 157–160. https://doi.org/10.1080/21678421.2021.1927103
ALSUNTANGLED GROUP, M. P. “ALSUntangled #61: melatonin.Amyotroph Lateral Scler Frontotemporal Degener 23, no. 1–2 (February 2022): 157–60. https://doi.org/10.1080/21678421.2021.1927103.
ALSUNTANGLED GROUP. ALSUntangled #61: melatonin. Amyotroph Lateral Scler Frontotemporal Degener. 2022 Feb;23(1–2):157–60.
ALSUNTANGLED GROUP, M. P. “ALSUntangled #61: melatonin.Amyotroph Lateral Scler Frontotemporal Degener, vol. 23, no. 1–2, Feb. 2022, pp. 157–60. Pubmed, doi:10.1080/21678421.2021.1927103.
ALSUNTANGLED GROUP. ALSUntangled #61: melatonin. Amyotroph Lateral Scler Frontotemporal Degener. 2022 Feb;23(1–2):157–160.

Published In

Amyotroph Lateral Scler Frontotemporal Degener

DOI

EISSN

2167-9223

Publication Date

February 2022

Volume

23

Issue

1-2

Start / End Page

157 / 160

Location

England

Related Subject Headings

  • Retrospective Studies
  • Melatonin
  • Humans
  • Amyotrophic Lateral Sclerosis
  • 3209 Neurosciences
  • 1109 Neurosciences
  • 1103 Clinical Sciences