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Sex determination without sex chromosomes.

Publication ,  Journal Article
Weber, C; Capel, B
Published in: Philos Trans R Soc Lond B Biol Sci
August 30, 2021

With or without sex chromosomes, sex determination is a synthesis of many molecular events that drives a community of cells towards a coordinated tissue fate. In this review, we will consider how a sex determination pathway can be engaged and stabilized without an inherited genetic determinant. In many reptilian species, no sex chromosomes have been identified, yet a conserved network of gene expression is initiated. Recent studies propose that epigenetic regulation mediates the effects of temperature on these genes through dynamic post-transcriptional, post-translational and metabolic pathways. It is likely that there is no singular regulator of sex determination, but rather an accumulation of molecular events that shift the scales towards one fate over another until a threshold is reached sufficient to maintain and stabilize one pathway and repress the alternative pathway. Investigations into the mechanism underlying sex determination without sex chromosomes should focus on cellular processes that are frequently activated by multiple stimuli or can synthesize multiple inputs and drive a coordinated response. This article is part of the theme issue 'Challenging the paradigm in sex chromosome evolution: empirical and theoretical insights with a focus on vertebrates (Part I)'.

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Published In

Philos Trans R Soc Lond B Biol Sci

DOI

EISSN

1471-2970

Publication Date

August 30, 2021

Volume

376

Issue

1832

Start / End Page

20200109

Location

England

Related Subject Headings

  • Vertebrates
  • Sex Determination Processes
  • Sex Chromosomes
  • Evolutionary Biology
  • Evolution, Molecular
  • Epigenesis, Genetic
  • Animals
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences
 

Citation

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Weber, C., & Capel, B. (2021). Sex determination without sex chromosomes. Philos Trans R Soc Lond B Biol Sci, 376(1832), 20200109. https://doi.org/10.1098/rstb.2020.0109
Weber, Ceri, and Blanche Capel. “Sex determination without sex chromosomes.Philos Trans R Soc Lond B Biol Sci 376, no. 1832 (August 30, 2021): 20200109. https://doi.org/10.1098/rstb.2020.0109.
Weber C, Capel B. Sex determination without sex chromosomes. Philos Trans R Soc Lond B Biol Sci. 2021 Aug 30;376(1832):20200109.
Weber, Ceri, and Blanche Capel. “Sex determination without sex chromosomes.Philos Trans R Soc Lond B Biol Sci, vol. 376, no. 1832, Aug. 2021, p. 20200109. Pubmed, doi:10.1098/rstb.2020.0109.
Weber C, Capel B. Sex determination without sex chromosomes. Philos Trans R Soc Lond B Biol Sci. 2021 Aug 30;376(1832):20200109.
Journal cover image

Published In

Philos Trans R Soc Lond B Biol Sci

DOI

EISSN

1471-2970

Publication Date

August 30, 2021

Volume

376

Issue

1832

Start / End Page

20200109

Location

England

Related Subject Headings

  • Vertebrates
  • Sex Determination Processes
  • Sex Chromosomes
  • Evolutionary Biology
  • Evolution, Molecular
  • Epigenesis, Genetic
  • Animals
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences