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Imaging genotyping of functional signaling pathways in lung squamous cell carcinoma using a radiomics approach.

Publication ,  Journal Article
Bak, SH; Park, H; Lee, HY; Kim, Y; Kim, H-L; Jung, S-H; Kim, H; Kim, J; Park, K
Published in: Scientific reports
February 2018

Imaging features can be useful for identifying distinct genomic differences and have predictive power for certain phenotypes attributed to genomic mutations. We aimed to identify predictive imaging biomarkers that underpin genomic alterations and clinical outcomes in lung squamous cell carcinoma (SQCC) using a radiomics approach. In 57 patients with lung SQCC who underwent preoperative computed tomography (CT) and whole-exome DNA sequencing, 63 quantitative imaging features were extracted from CT and 73 clinicoradiological features including imaging features were classified into 8 categories: clinical, global, histogram-based, lung cancer-specific, shape, local, regional, and emphysema. Mutational profiles for core signaling pathways of lung SQCC were classified into five categories: redox stress, apoptosis, proliferation, differentiation, and chromatin remodelers. Range and right lung volume was significantly associated with alternation of apoptosis and proliferation pathway (p = 0.03, and p = 0.03). Energy was associated with the redox stress pathway (p = 0.06). None of the clinicoradiological features showed any significant association with the alteration of differentiation and chromatin remodelers pathway. This study showed that radiomic features indicating five different functional pathways of lung SQCC were different form one another. Radiomics approaches to lung SQCC have the potential to noninvasively predict alterations in core signaling pathways and clinical outcome.

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Published In

Scientific reports

DOI

EISSN

2045-2322

ISSN

2045-2322

Publication Date

February 2018

Volume

8

Issue

1

Start / End Page

3284

Related Subject Headings

  • Tomography, Emission-Computed
  • Signal Transduction
  • Radiometry
  • Mutation
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Humans
  • Genotype
  • Female
 

Citation

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Bak, S. H., Park, H., Lee, H. Y., Kim, Y., Kim, H.-L., Jung, S.-H., … Park, K. (2018). Imaging genotyping of functional signaling pathways in lung squamous cell carcinoma using a radiomics approach. Scientific Reports, 8(1), 3284. https://doi.org/10.1038/s41598-018-21706-1
Bak, So Hyeon, Hyunjin Park, Ho Yun Lee, Youngwook Kim, Hyung-Lae Kim, Sin-Ho Jung, Hyeseung Kim, Jonghoon Kim, and Keunchil Park. “Imaging genotyping of functional signaling pathways in lung squamous cell carcinoma using a radiomics approach.Scientific Reports 8, no. 1 (February 2018): 3284. https://doi.org/10.1038/s41598-018-21706-1.
Bak SH, Park H, Lee HY, Kim Y, Kim H-L, Jung S-H, et al. Imaging genotyping of functional signaling pathways in lung squamous cell carcinoma using a radiomics approach. Scientific reports. 2018 Feb;8(1):3284.
Bak, So Hyeon, et al. “Imaging genotyping of functional signaling pathways in lung squamous cell carcinoma using a radiomics approach.Scientific Reports, vol. 8, no. 1, Feb. 2018, p. 3284. Epmc, doi:10.1038/s41598-018-21706-1.
Bak SH, Park H, Lee HY, Kim Y, Kim H-L, Jung S-H, Kim H, Kim J, Park K. Imaging genotyping of functional signaling pathways in lung squamous cell carcinoma using a radiomics approach. Scientific reports. 2018 Feb;8(1):3284.

Published In

Scientific reports

DOI

EISSN

2045-2322

ISSN

2045-2322

Publication Date

February 2018

Volume

8

Issue

1

Start / End Page

3284

Related Subject Headings

  • Tomography, Emission-Computed
  • Signal Transduction
  • Radiometry
  • Mutation
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Humans
  • Genotype
  • Female