Conditional specification of endomesoderm.
Publication
, Journal Article
McClay, DR; Croce, JC; Warner, JF
Published in: Cells & development
September 2021
Early in animal development many cells are conditionally specified based on observations that those cells can be directed toward alternate fates. The endomesoderm is so named because early specification produces cells that often have been observed to simultaneously express both early endoderm and mesoderm transcription factors. Experiments with these cells demonstrate that their progeny can directed entirely toward endoderm or mesoderm, whereas normally they establish both germ layers. This review examines the mechanisms that initiate the conditional endomesoderm state, its metastability, and the mechanisms that resolve that state into definitive endoderm and mesoderm.
Duke Scholars
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Published In
Cells & development
DOI
EISSN
2667-2901
ISSN
2667-291X
Publication Date
September 2021
Volume
167
Start / End Page
203716
Related Subject Headings
- Signal Transduction
- Sea Urchins
- Models, Biological
- Mesoderm
- Humans
- Endoderm
- Body Patterning
- Animals
Citation
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McClay, D. R., Croce, J. C., & Warner, J. F. (2021). Conditional specification of endomesoderm. Cells & Development, 167, 203716. https://doi.org/10.1016/j.cdev.2021.203716
McClay, David R., Jenifer C. Croce, and Jacob F. Warner. “Conditional specification of endomesoderm.” Cells & Development 167 (September 2021): 203716. https://doi.org/10.1016/j.cdev.2021.203716.
McClay DR, Croce JC, Warner JF. Conditional specification of endomesoderm. Cells & development. 2021 Sep;167:203716.
McClay, David R., et al. “Conditional specification of endomesoderm.” Cells & Development, vol. 167, Sept. 2021, p. 203716. Epmc, doi:10.1016/j.cdev.2021.203716.
McClay DR, Croce JC, Warner JF. Conditional specification of endomesoderm. Cells & development. 2021 Sep;167:203716.
Published In
Cells & development
DOI
EISSN
2667-2901
ISSN
2667-291X
Publication Date
September 2021
Volume
167
Start / End Page
203716
Related Subject Headings
- Signal Transduction
- Sea Urchins
- Models, Biological
- Mesoderm
- Humans
- Endoderm
- Body Patterning
- Animals