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Formal Synthesis of Adaptive Droplet Routing for MEDA Biochips

Publication ,  Conference
Elfar, M; Liang, TC; Chakrabarty, K; Pajic, M
Published in: Proceedings -Design, Automation and Test in Europe, DATE
February 1, 2021

A digital microfluidic biochip (DMFB) enables the miniaturization of immunoassays, point-of-care clinical diagnostics, and DNA sequencing. A recent generation of DMFBs uses a micro-electrode-dot-array (MEDA) architecture, which provides fine-grained control of droplets and real-time droplet sensing using CMOS technology. However, microelectrodes in a MEDA biochip can degrade due to charge trapping when they are repeatedly charged and discharged during bioassay execution; such degradation leads to the failure of microelectrodes and erroneous bioassay outcomes. To address this problem, we first introduce a new microelectrode-cell design such that we can obtain the health status of all the microelectrodes in a MEDA biochip by employing the inherent sensing mechanism. Next, we present a stochastic game-based model for droplet manipulation, and a formal synthesis method for droplet routing that can dynamically change droplet transportation routes. This adaptation is based on the real-time health information obtained from microelectrodes. Comprehensive simulation results for four real-life bioassays show that our method increases the likelihood of successful bioassay completion with negligible impact on time-to-results.

Duke Scholars

Published In

Proceedings -Design, Automation and Test in Europe, DATE

DOI

ISSN

1530-1591

Publication Date

February 1, 2021

Volume

2021-February

Start / End Page

324 / 329
 

Citation

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Elfar, M., Liang, T. C., Chakrabarty, K., & Pajic, M. (2021). Formal Synthesis of Adaptive Droplet Routing for MEDA Biochips. In Proceedings -Design, Automation and Test in Europe, DATE (Vol. 2021-February, pp. 324–329). https://doi.org/10.23919/DATE51398.2021.9474144
Elfar, M., T. C. Liang, K. Chakrabarty, and M. Pajic. “Formal Synthesis of Adaptive Droplet Routing for MEDA Biochips.” In Proceedings -Design, Automation and Test in Europe, DATE, 2021-February:324–29, 2021. https://doi.org/10.23919/DATE51398.2021.9474144.
Elfar M, Liang TC, Chakrabarty K, Pajic M. Formal Synthesis of Adaptive Droplet Routing for MEDA Biochips. In: Proceedings -Design, Automation and Test in Europe, DATE. 2021. p. 324–9.
Elfar, M., et al. “Formal Synthesis of Adaptive Droplet Routing for MEDA Biochips.” Proceedings -Design, Automation and Test in Europe, DATE, vol. 2021-February, 2021, pp. 324–29. Scopus, doi:10.23919/DATE51398.2021.9474144.
Elfar M, Liang TC, Chakrabarty K, Pajic M. Formal Synthesis of Adaptive Droplet Routing for MEDA Biochips. Proceedings -Design, Automation and Test in Europe, DATE. 2021. p. 324–329.

Published In

Proceedings -Design, Automation and Test in Europe, DATE

DOI

ISSN

1530-1591

Publication Date

February 1, 2021

Volume

2021-February

Start / End Page

324 / 329