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Integrating Biomaterials and Genome Editing Approaches to Advance Biomedical Science.

Publication ,  Book
Abdeen, AA; Cosgrove, BD; Gersbach, CA; Saha, K
July 2021

The recent discovery and subsequent development of the CRISPR-Cas9 (clustered regularly interspaced short palindromic repeat-CRISPR-associated protein 9) platform as a precise genome editing tool have transformed biomedicine. As these CRISPR-based tools have matured, multiple stages of the gene editing process and the bioengineering of human cells and tissues have advanced. Here, we highlight recent intersections in the development of biomaterials and genome editing technologies. These intersections include the delivery of macromolecules, where biomaterial platforms have been harnessed to enable nonviral delivery of genome engineering tools to cells and tissues in vivo. Further, engineering native-like biomaterial platforms for cell culture facilitates complex modeling of human development and disease when combined with genome engineering tools. Deeper integration of biomaterial platforms in these fields could play a significant role in enabling new breakthroughs in the application of gene editing for the treatment of human disease.

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DOI

Publication Date

July 2021

Volume

23

Start / End Page

493 / 516

Related Subject Headings

  • Humans
  • Gene Editing
  • CRISPR-Cas Systems
  • Biomedical Engineering
  • Biocompatible Materials
  • 0903 Biomedical Engineering
 

Citation

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Abdeen, A. A., Cosgrove, B. D., Gersbach, C. A., & Saha, K. (2021). Integrating Biomaterials and Genome Editing Approaches to Advance Biomedical Science. (Vol. 23, pp. 493–516). https://doi.org/10.1146/annurev-bioeng-122019-121602
Abdeen, Amr A., Brian D. Cosgrove, Charles A. Gersbach, and Krishanu Saha. Integrating Biomaterials and Genome Editing Approaches to Advance Biomedical Science. Vol. 23, 2021. https://doi.org/10.1146/annurev-bioeng-122019-121602.
Abdeen AA, Cosgrove BD, Gersbach CA, Saha K. Integrating Biomaterials and Genome Editing Approaches to Advance Biomedical Science. Vol. 23. 2021.
Abdeen, Amr A., et al. Integrating Biomaterials and Genome Editing Approaches to Advance Biomedical Science. Vol. 23, 2021, pp. 493–516. Epmc, doi:10.1146/annurev-bioeng-122019-121602.
Abdeen AA, Cosgrove BD, Gersbach CA, Saha K. Integrating Biomaterials and Genome Editing Approaches to Advance Biomedical Science. 2021. p. 493–516.

DOI

Publication Date

July 2021

Volume

23

Start / End Page

493 / 516

Related Subject Headings

  • Humans
  • Gene Editing
  • CRISPR-Cas Systems
  • Biomedical Engineering
  • Biocompatible Materials
  • 0903 Biomedical Engineering