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Mind the gap from research laboratory to clinic: Challenges and opportunities for next-generation assays in human diseases.

Publication ,  Journal Article
D'Souza, MP; Palin, AC; Calder, T; Golding, H; Kleinstein, SH; Milliken, EL; O'Connor, D; Tomaras, G; Warren, J; Boggiano, C
Published in: Vaccine
August 31, 2021

Modern vaccinology has experienced major conceptual and technological advances over the past 30 years. These include atomic-level structures driving immunogen design, new vaccine delivery methods, powerful adjuvants, and novel animal models. In addition, utilizing advanced assays to learn how the immune system senses a pathogen and orchestrates protective immunity has been critical in the design of effective vaccines and therapeutics. The National Institute of Allergy and Infectious Diseases of the National Institutes of Health convened a workshop in September 2020 focused on next generation assays for vaccine development (Table 1). The workshop focused on four critical pathogens: severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) and human immunodeficiency virus (HIV)-which have no licensed vaccines-and tuberculosis (TB) and influenza-both of which are in critical need of improved vaccines. The goal was to share progress and lessons learned, and to identify any commonalities that can be leveraged to design vaccines and therapeutics.

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Published In

Vaccine

DOI

EISSN

1873-2518

Publication Date

August 31, 2021

Volume

39

Issue

37

Start / End Page

5233 / 5239

Location

Netherlands

Related Subject Headings

  • Virology
  • Vaccinology
  • United States
  • Tuberculosis
  • SARS-CoV-2
  • Laboratories
  • Humans
  • COVID-19
  • Animals
  • 42 Health sciences
 

Citation

APA
Chicago
ICMJE
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D’Souza, M. P., Palin, A. C., Calder, T., Golding, H., Kleinstein, S. H., Milliken, E. L., … Boggiano, C. (2021). Mind the gap from research laboratory to clinic: Challenges and opportunities for next-generation assays in human diseases. Vaccine, 39(37), 5233–5239. https://doi.org/10.1016/j.vaccine.2021.07.071
D’Souza, M Patricia, Amy C. Palin, Thomas Calder, Hana Golding, Steven H. Kleinstein, Erin L. Milliken, David O’Connor, Georgia Tomaras, Jon Warren, and Cesar Boggiano. “Mind the gap from research laboratory to clinic: Challenges and opportunities for next-generation assays in human diseases.Vaccine 39, no. 37 (August 31, 2021): 5233–39. https://doi.org/10.1016/j.vaccine.2021.07.071.
D’Souza MP, Palin AC, Calder T, Golding H, Kleinstein SH, Milliken EL, et al. Mind the gap from research laboratory to clinic: Challenges and opportunities for next-generation assays in human diseases. Vaccine. 2021 Aug 31;39(37):5233–9.
D’Souza, M. Patricia, et al. “Mind the gap from research laboratory to clinic: Challenges and opportunities for next-generation assays in human diseases.Vaccine, vol. 39, no. 37, Aug. 2021, pp. 5233–39. Pubmed, doi:10.1016/j.vaccine.2021.07.071.
D’Souza MP, Palin AC, Calder T, Golding H, Kleinstein SH, Milliken EL, O’Connor D, Tomaras G, Warren J, Boggiano C. Mind the gap from research laboratory to clinic: Challenges and opportunities for next-generation assays in human diseases. Vaccine. 2021 Aug 31;39(37):5233–5239.
Journal cover image

Published In

Vaccine

DOI

EISSN

1873-2518

Publication Date

August 31, 2021

Volume

39

Issue

37

Start / End Page

5233 / 5239

Location

Netherlands

Related Subject Headings

  • Virology
  • Vaccinology
  • United States
  • Tuberculosis
  • SARS-CoV-2
  • Laboratories
  • Humans
  • COVID-19
  • Animals
  • 42 Health sciences