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Of Rats and Men: a Translational Model To Understand Vancomycin Pharmacokinetic/Toxicodynamic Relationships.

Publication ,  Journal Article
Scheetz, MH; Pais, GM; Lodise, TP; Tong, SYC; Davis, JS; O'Donnell, JN; Liu, J; Neely, M; Prozialeck, WC; Lamar, PC; Rhodes, NJ; Holland, T ...
Published in: Antimicrob Agents Chemother
September 17, 2021

Vancomycin area under the concentration curve (AUC) is known to predict vancomycin-induced acute kidney injury (AKI). Data were analyzed from a rat model (n = 48) and two prospective clinical studies (PROVIDE [n = 263] and CAMERA2 [n = 291]). A logit-link model was used to calculate the multiplicative factors between the probability of AKI from clinical studies and in the rat. The rat was 2.7 to 4.2 times more sensitive to AKI between AUCs of 199.5 and 794.3 mg·h/liter, respectively.

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Published In

Antimicrob Agents Chemother

DOI

EISSN

1098-6596

Publication Date

September 17, 2021

Volume

65

Issue

10

Start / End Page

e0106021

Location

United States

Related Subject Headings

  • Vancomycin
  • Rats
  • Prospective Studies
  • Microbiology
  • Area Under Curve
  • Anti-Bacterial Agents
  • Animals
  • Acute Kidney Injury
  • 3214 Pharmacology and pharmaceutical sciences
  • 3207 Medical microbiology
 

Citation

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Scheetz, M. H., Pais, G. M., Lodise, T. P., Tong, S. Y. C., Davis, J. S., O’Donnell, J. N., … Avedissian, S. N. (2021). Of Rats and Men: a Translational Model To Understand Vancomycin Pharmacokinetic/Toxicodynamic Relationships. Antimicrob Agents Chemother, 65(10), e0106021. https://doi.org/10.1128/AAC.01060-21
Scheetz, Marc H., Gwendolyn M. Pais, Thomas P. Lodise, Steven Y. C. Tong, Joshua S. Davis, J Nicholas O’Donnell, Jiajun Liu, et al. “Of Rats and Men: a Translational Model To Understand Vancomycin Pharmacokinetic/Toxicodynamic Relationships.Antimicrob Agents Chemother 65, no. 10 (September 17, 2021): e0106021. https://doi.org/10.1128/AAC.01060-21.
Scheetz MH, Pais GM, Lodise TP, Tong SYC, Davis JS, O’Donnell JN, et al. Of Rats and Men: a Translational Model To Understand Vancomycin Pharmacokinetic/Toxicodynamic Relationships. Antimicrob Agents Chemother. 2021 Sep 17;65(10):e0106021.
Scheetz, Marc H., et al. “Of Rats and Men: a Translational Model To Understand Vancomycin Pharmacokinetic/Toxicodynamic Relationships.Antimicrob Agents Chemother, vol. 65, no. 10, Sept. 2021, p. e0106021. Pubmed, doi:10.1128/AAC.01060-21.
Scheetz MH, Pais GM, Lodise TP, Tong SYC, Davis JS, O’Donnell JN, Liu J, Neely M, Prozialeck WC, Lamar PC, Rhodes NJ, Holland T, Avedissian SN. Of Rats and Men: a Translational Model To Understand Vancomycin Pharmacokinetic/Toxicodynamic Relationships. Antimicrob Agents Chemother. 2021 Sep 17;65(10):e0106021.

Published In

Antimicrob Agents Chemother

DOI

EISSN

1098-6596

Publication Date

September 17, 2021

Volume

65

Issue

10

Start / End Page

e0106021

Location

United States

Related Subject Headings

  • Vancomycin
  • Rats
  • Prospective Studies
  • Microbiology
  • Area Under Curve
  • Anti-Bacterial Agents
  • Animals
  • Acute Kidney Injury
  • 3214 Pharmacology and pharmaceutical sciences
  • 3207 Medical microbiology