Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel

DunedinPACE: A DNA methylation biomarker of the Pace of Aging

Publication ,  Journal Article
Belsky, DW; Caspi, A; Corcoran, DL; Sugden, K; Poulton, R; Arseneault, L; Baccarelli, A; Chamarti, K; Gao, X; Hannon, E; Harrington, HL ...
2021

Measures to quantify changes in the pace of biological aging in response to intervention are needed to evaluate geroprotective interventions for humans. We used data from the Dunedin Study 1972-3 birth cohort tracking within-individual decline in 19 indicators of organ-system integrity across four time points spanning two decades to model Pace of Aging. We distilled this two-decade Pace of Aging into a single-time-point DNA-methylation blood-test using elastic-net regression and a DNA-methylation dataset restricted to exclude probes with low test-retest reliability. We evaluated the resulting measure, named DunedinPACE, in five additional datasets. DunedinPACE showed high test-retest reliability, was associated with morbidity, disability, and mortality, and indicated faster aging in young adults with childhood adversity. DunedinPACE effect-sizes were similar to GrimAge Clock effect-sizes. In analysis of morbidity, disability, and mortality, DunedinPACE and added incremental prediction beyond GrimAge. DunedinPACE is a novel blood biomarker of the pace of aging for gerontology and geroscience.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

DOI

Publication Date

2021
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Belsky, D. W., Caspi, A., Corcoran, D. L., Sugden, K., Poulton, R., Arseneault, L., … Moffitt, T. E. (2021). DunedinPACE: A DNA methylation biomarker of the Pace of Aging. https://doi.org/10.1101/2021.08.30.21262858
Belsky, D. W., A. Caspi, D. L. Corcoran, K. Sugden, R. Poulton, L. Arseneault, A. Baccarelli, et al. “DunedinPACE: A DNA methylation biomarker of the Pace of Aging,” 2021. https://doi.org/10.1101/2021.08.30.21262858.
Belsky DW, Caspi A, Corcoran DL, Sugden K, Poulton R, Arseneault L, et al. DunedinPACE: A DNA methylation biomarker of the Pace of Aging. 2021;
Belsky, D. W., et al. DunedinPACE: A DNA methylation biomarker of the Pace of Aging. 2021. Epmc, doi:10.1101/2021.08.30.21262858.
Belsky DW, Caspi A, Corcoran DL, Sugden K, Poulton R, Arseneault L, Baccarelli A, Chamarti K, Gao X, Hannon E, Harrington HL, Houts R, Kothari M, Kwon D, Mill J, Schwartz J, Vokonas P, Wang C, Williams B, Moffitt TE. DunedinPACE: A DNA methylation biomarker of the Pace of Aging. 2021;

DOI

Publication Date

2021