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Fab and Fc contribute to maximal protection against SARS-CoV-2 following NVX-CoV2373 subunit vaccine with Matrix-M vaccination.

Publication ,  Journal Article
Gorman, MJ; Patel, N; Guebre-Xabier, M; Zhu, AL; Atyeo, C; Pullen, KM; Loos, C; Goez-Gazi, Y; Carrion, R; Tian, J-H; Yuan, D; Bowman, KA ...
Published in: Cell reports. Medicine
September 2021

Recently approved vaccines have shown remarkable efficacy in limiting SARS-CoV-2-associated disease. However, with the variety of vaccines, immunization strategies, and waning antibody titers, defining the correlates of immunity across a spectrum of antibody titers is urgently required. Thus, we profiled the humoral immune response in a cohort of non-human primates immunized with a recombinant SARS-CoV-2 spike glycoprotein (NVX-CoV2373) at two doses, administered as a single- or two-dose regimen. Both antigen dose and boosting significantly altered neutralization titers and Fc-effector profiles, driving unique vaccine-induced antibody fingerprints. Combined differences in antibody effector functions and neutralization were associated with distinct levels of protection in the upper and lower respiratory tract. Moreover, NVX-CoV2373 elicited antibodies that functionally targeted emerging SARS-CoV-2 variants. Collectively, the data presented here suggest that a single dose may prevent disease via combined Fc/Fab functions but that two doses may be essential to block further transmission of SARS-CoV-2 and emerging variants.

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Published In

Cell reports. Medicine

DOI

EISSN

2666-3791

ISSN

2666-3791

Publication Date

September 2021

Volume

2

Issue

9

Start / End Page

100405

Related Subject Headings

  • Vaccination
  • Spike Glycoprotein, Coronavirus
  • Saponins
  • SARS-CoV-2
  • Primates
  • Nanoparticles
  • Male
  • Macaca mulatta
  • Immunoglobulin Fc Fragments
  • Immunoglobulin Fab Fragments
 

Citation

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MLA
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Gorman, M. J., Patel, N., Guebre-Xabier, M., Zhu, A. L., Atyeo, C., Pullen, K. M., … Alter, G. (2021). Fab and Fc contribute to maximal protection against SARS-CoV-2 following NVX-CoV2373 subunit vaccine with Matrix-M vaccination. Cell Reports. Medicine, 2(9), 100405. https://doi.org/10.1016/j.xcrm.2021.100405
Gorman, Matthew J., Nita Patel, Mimi Guebre-Xabier, Alex L. Zhu, Caroline Atyeo, Krista M. Pullen, Carolin Loos, et al. “Fab and Fc contribute to maximal protection against SARS-CoV-2 following NVX-CoV2373 subunit vaccine with Matrix-M vaccination.Cell Reports. Medicine 2, no. 9 (September 2021): 100405. https://doi.org/10.1016/j.xcrm.2021.100405.
Gorman MJ, Patel N, Guebre-Xabier M, Zhu AL, Atyeo C, Pullen KM, et al. Fab and Fc contribute to maximal protection against SARS-CoV-2 following NVX-CoV2373 subunit vaccine with Matrix-M vaccination. Cell reports Medicine. 2021 Sep;2(9):100405.
Gorman, Matthew J., et al. “Fab and Fc contribute to maximal protection against SARS-CoV-2 following NVX-CoV2373 subunit vaccine with Matrix-M vaccination.Cell Reports. Medicine, vol. 2, no. 9, Sept. 2021, p. 100405. Epmc, doi:10.1016/j.xcrm.2021.100405.
Gorman MJ, Patel N, Guebre-Xabier M, Zhu AL, Atyeo C, Pullen KM, Loos C, Goez-Gazi Y, Carrion R, Tian J-H, Yuan D, Bowman KA, Zhou B, Maciejewski S, McGrath ME, Logue J, Frieman MB, Montefiori D, Mann C, Schendel S, Amanat F, Krammer F, Saphire EO, Lauffenburger DA, Greene AM, Portnoff AD, Massare MJ, Ellingsworth L, Glenn G, Smith G, Alter G. Fab and Fc contribute to maximal protection against SARS-CoV-2 following NVX-CoV2373 subunit vaccine with Matrix-M vaccination. Cell reports Medicine. 2021 Sep;2(9):100405.

Published In

Cell reports. Medicine

DOI

EISSN

2666-3791

ISSN

2666-3791

Publication Date

September 2021

Volume

2

Issue

9

Start / End Page

100405

Related Subject Headings

  • Vaccination
  • Spike Glycoprotein, Coronavirus
  • Saponins
  • SARS-CoV-2
  • Primates
  • Nanoparticles
  • Male
  • Macaca mulatta
  • Immunoglobulin Fc Fragments
  • Immunoglobulin Fab Fragments