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Emerging roles of Dectin-1 in noninfectious settings and in the CNS.

Publication ,  Journal Article
Deerhake, ME; Shinohara, ML
Published in: Trends in immunology
October 2021

Dectin-1 is a C-type lectin receptor (CLR) expressed on the surface of various mammalian myeloid cells. Dectin-1 recognizes β-glucans and elicits antifungal proinflammatory immune responses. Recent studies have begun to examine the biology of Dectin-1 in previously less explored settings, such as homeostasis, sterile inflammation, and in the central nervous system. Indeed, in certain contexts, Dectin-1 is now known to promote tolerance, and anti-inflammatory and neuroprotective responses. In this review, we provide an overview of the current understanding of the roles of Dectin-1 in immunology beyond the context of fungal infections, mainly focusing on in vivo neuroimmunology studies, which could reveal new therapeutic approaches to modify innate immune responses in neurologic disorders.

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Published In

Trends in immunology

DOI

EISSN

1471-4981

ISSN

1471-4906

Publication Date

October 2021

Volume

42

Issue

10

Start / End Page

891 / 903

Related Subject Headings

  • beta-Glucans
  • Lectins, C-Type
  • Immunology
  • Immunity, Innate
  • Central Nervous System
  • Animals
  • 3204 Immunology
  • 3101 Biochemistry and cell biology
  • 1107 Immunology
 

Citation

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ICMJE
MLA
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Deerhake, M. E., & Shinohara, M. L. (2021). Emerging roles of Dectin-1 in noninfectious settings and in the CNS. Trends in Immunology, 42(10), 891–903. https://doi.org/10.1016/j.it.2021.08.005
Deerhake, M Elizabeth, and Mari L. Shinohara. “Emerging roles of Dectin-1 in noninfectious settings and in the CNS.Trends in Immunology 42, no. 10 (October 2021): 891–903. https://doi.org/10.1016/j.it.2021.08.005.
Deerhake ME, Shinohara ML. Emerging roles of Dectin-1 in noninfectious settings and in the CNS. Trends in immunology. 2021 Oct;42(10):891–903.
Deerhake, M. Elizabeth, and Mari L. Shinohara. “Emerging roles of Dectin-1 in noninfectious settings and in the CNS.Trends in Immunology, vol. 42, no. 10, Oct. 2021, pp. 891–903. Epmc, doi:10.1016/j.it.2021.08.005.
Deerhake ME, Shinohara ML. Emerging roles of Dectin-1 in noninfectious settings and in the CNS. Trends in immunology. 2021 Oct;42(10):891–903.
Journal cover image

Published In

Trends in immunology

DOI

EISSN

1471-4981

ISSN

1471-4906

Publication Date

October 2021

Volume

42

Issue

10

Start / End Page

891 / 903

Related Subject Headings

  • beta-Glucans
  • Lectins, C-Type
  • Immunology
  • Immunity, Innate
  • Central Nervous System
  • Animals
  • 3204 Immunology
  • 3101 Biochemistry and cell biology
  • 1107 Immunology