
Autophagy and mitophagy in ALS.
Publication
, Journal Article
Evans, CS; Holzbaur, ELF
Published in: Neurobiol Dis
February 2019
Amyotrophic lateral sclerosis (ALS) is a debilitating and incurable disease involving the loss of motor neurons and subsequent muscle atrophy. Genetic studies have implicated deficits in autophagy and/or mitophagy in the onset of the disease. Here we review recent progress in our understanding of the pathways for autophagy and mitophagy in neurons, and how these pathways may be affected by mutations in genes including DCTN1, OPTN, TBK1, VCP, and C9ORF72. We also discuss the implications of modulating autophagy in ALS, highlighting both the potential of the approach and the concerns raised by targeting this pathway as a therapeutic strategy in neurodegenerative disease.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
Neurobiol Dis
DOI
EISSN
1095-953X
Publication Date
February 2019
Volume
122
Start / End Page
35 / 40
Location
United States
Related Subject Headings
- Neurons
- Neurology & Neurosurgery
- Mitophagy
- Humans
- Autophagy
- Animals
- Amyotrophic Lateral Sclerosis
- 3209 Neurosciences
- 3101 Biochemistry and cell biology
- 1109 Neurosciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Evans, C. S., & Holzbaur, E. L. F. (2019). Autophagy and mitophagy in ALS. Neurobiol Dis, 122, 35–40. https://doi.org/10.1016/j.nbd.2018.07.005
Evans, Chantell S., and Erika L. F. Holzbaur. “Autophagy and mitophagy in ALS.” Neurobiol Dis 122 (February 2019): 35–40. https://doi.org/10.1016/j.nbd.2018.07.005.
Evans CS, Holzbaur ELF. Autophagy and mitophagy in ALS. Neurobiol Dis. 2019 Feb;122:35–40.
Evans, Chantell S., and Erika L. F. Holzbaur. “Autophagy and mitophagy in ALS.” Neurobiol Dis, vol. 122, Feb. 2019, pp. 35–40. Pubmed, doi:10.1016/j.nbd.2018.07.005.
Evans CS, Holzbaur ELF. Autophagy and mitophagy in ALS. Neurobiol Dis. 2019 Feb;122:35–40.

Published In
Neurobiol Dis
DOI
EISSN
1095-953X
Publication Date
February 2019
Volume
122
Start / End Page
35 / 40
Location
United States
Related Subject Headings
- Neurons
- Neurology & Neurosurgery
- Mitophagy
- Humans
- Autophagy
- Animals
- Amyotrophic Lateral Sclerosis
- 3209 Neurosciences
- 3101 Biochemistry and cell biology
- 1109 Neurosciences