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Identifying Risk Factors for Blindness From Glaucoma at First Presentation to a Tertiary Clinic.

Publication ,  Conference
Shi, A; Berchuck, SI; Jammal, AA; Singh, G; Hunt, S; Roche, K; Mukherjee, S; Medeiros, FA
Published in: Am J Ophthalmol
June 2023

PURPOSE: Glaucoma is the leading cause of irreversible blindness, a crippling disability resulting in higher risks of chronic health conditions. To better understand disparities in blindness risk, we identified risk factors of blindness on first presentation to a glaucoma clinic using a large clinical database. DESIGN: Retrospective cross-sectional study. METHODS: We used electronic health records of glaucoma patients from the Duke Ophthalmic Registry. International Classification of Diseases codes were used to identify glaucoma and exclude concurrent diseases. Blindness classification was based on the definition of legal blindness. Risk factors included gender, race, marital status, age, intraocular pressure, diabetes history, income level, and education. Odds ratios (ORs) and 95% CIs were calculated for risk factors using univariable and multivariable logistic regression. RESULTS: Our cohort consisted of 3753 patients, with 192 (5%) blind on first presentation. In univariable models, African American / Black race (OR 2.48, 95% CI 1.83-3.36), single marital status (1.74, 95% CI 1.25-2.44), prior diabetes diagnosis (2.23, 95% CI 1.52-3.27), and higher intraocular pressure (1.29 per 1 SD higher, 95% CI 1.13-1.46) were associated with increased risk of presenting blind, whereas higher annual income (0.75, 95% CI 0.65-0.86) and education (0.77, 95% CI 0.69-0.85) were associated with lower risk. These associations remained significant and in the same direction in a multivariable model apart from income, which became insignificant. CONCLUSIONS: Using a large real-world clinical database, we identified risk factors associated with presentation with blindness among glaucoma patients. Our results highlight disparities in health care outcomes and indicate the importance of targeted education to reduce disparities in blindness.

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Published In

Am J Ophthalmol

DOI

EISSN

1879-1891

Publication Date

June 2023

Volume

250

Start / End Page

130 / 137

Location

United States

Related Subject Headings

  • Risk Factors
  • Retrospective Studies
  • Ophthalmology & Optometry
  • Intraocular Pressure
  • Humans
  • Glaucoma
  • Cross-Sectional Studies
  • Blindness
  • 1117 Public Health and Health Services
  • 1113 Opthalmology and Optometry
 

Citation

APA
Chicago
ICMJE
MLA
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Shi, A., Berchuck, S. I., Jammal, A. A., Singh, G., Hunt, S., Roche, K., … Medeiros, F. A. (2023). Identifying Risk Factors for Blindness From Glaucoma at First Presentation to a Tertiary Clinic. In Am J Ophthalmol (Vol. 250, pp. 130–137). United States. https://doi.org/10.1016/j.ajo.2023.02.006
Shi, Alyssa, Samuel I. Berchuck, Alessandro A. Jammal, Geetika Singh, Sydney Hunt, Kimberly Roche, Sayan Mukherjee, and Felipe A. Medeiros. “Identifying Risk Factors for Blindness From Glaucoma at First Presentation to a Tertiary Clinic.” In Am J Ophthalmol, 250:130–37, 2023. https://doi.org/10.1016/j.ajo.2023.02.006.
Shi A, Berchuck SI, Jammal AA, Singh G, Hunt S, Roche K, et al. Identifying Risk Factors for Blindness From Glaucoma at First Presentation to a Tertiary Clinic. In: Am J Ophthalmol. 2023. p. 130–7.
Shi, Alyssa, et al. “Identifying Risk Factors for Blindness From Glaucoma at First Presentation to a Tertiary Clinic.Am J Ophthalmol, vol. 250, 2023, pp. 130–37. Pubmed, doi:10.1016/j.ajo.2023.02.006.
Shi A, Berchuck SI, Jammal AA, Singh G, Hunt S, Roche K, Mukherjee S, Medeiros FA. Identifying Risk Factors for Blindness From Glaucoma at First Presentation to a Tertiary Clinic. Am J Ophthalmol. 2023. p. 130–137.
Journal cover image

Published In

Am J Ophthalmol

DOI

EISSN

1879-1891

Publication Date

June 2023

Volume

250

Start / End Page

130 / 137

Location

United States

Related Subject Headings

  • Risk Factors
  • Retrospective Studies
  • Ophthalmology & Optometry
  • Intraocular Pressure
  • Humans
  • Glaucoma
  • Cross-Sectional Studies
  • Blindness
  • 1117 Public Health and Health Services
  • 1113 Opthalmology and Optometry