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Point-of-care antimicrobial coating protects orthopaedic implants from bacterial challenge.

Publication ,  Journal Article
Xi, W; Hegde, V; Zoller, SD; Park, HY; Hart, CM; Kondo, T; Hamad, CD; Hu, Y; Loftin, AH; Johansen, DO; Burke, Z; Clarkson, S; Ishmael, C ...
Published in: Nature communications
September 2021

Implant related infections are the most common cause of joint arthroplasty failure, requiring revision surgeries and a new implant, resulting in a cost of $8.6 billion annually. To address this problem, we created a class of coating technology that is applied in the operating room, in a procedure that takes less than 10 min, and can incorporate any desired antibiotic. Our coating technology uses an in situ coupling reaction of branched poly(ethylene glycol) and poly(allyl mercaptan) (PEG-PAM) polymers to generate an amphiphilic polymeric coating. We show in vivo efficacy in preventing implant infection in both post-arthroplasty infection and post-spinal surgery infection mouse models. Our technology displays efficacy with or without systemic antibiotics, the standard of care. Our coating technology is applied in a clinically relevant time frame, does not require modification of implant manufacturing process, and does not change the implant shelf life.

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Published In

Nature communications

DOI

EISSN

2041-1723

ISSN

2041-1723

Publication Date

September 2021

Volume

12

Issue

1

Start / End Page

5473

Related Subject Headings

  • Treatment Outcome
  • Staphylococcus aureus
  • Staphylococcal Infections
  • Prosthesis-Related Infections
  • Prostheses and Implants
  • Polymers
  • Polyethylene Glycols
  • Point-of-Care Systems
  • Mice, Inbred C57BL
  • Mice
 

Citation

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Xi, W., Hegde, V., Zoller, S. D., Park, H. Y., Hart, C. M., Kondo, T., … Segura, T. (2021). Point-of-care antimicrobial coating protects orthopaedic implants from bacterial challenge. Nature Communications, 12(1), 5473. https://doi.org/10.1038/s41467-021-25383-z
Xi, Weixian, Vishal Hegde, Stephen D. Zoller, Howard Y. Park, Christopher M. Hart, Takeru Kondo, Christopher D. Hamad, et al. “Point-of-care antimicrobial coating protects orthopaedic implants from bacterial challenge.Nature Communications 12, no. 1 (September 2021): 5473. https://doi.org/10.1038/s41467-021-25383-z.
Xi W, Hegde V, Zoller SD, Park HY, Hart CM, Kondo T, et al. Point-of-care antimicrobial coating protects orthopaedic implants from bacterial challenge. Nature communications. 2021 Sep;12(1):5473.
Xi, Weixian, et al. “Point-of-care antimicrobial coating protects orthopaedic implants from bacterial challenge.Nature Communications, vol. 12, no. 1, Sept. 2021, p. 5473. Epmc, doi:10.1038/s41467-021-25383-z.
Xi W, Hegde V, Zoller SD, Park HY, Hart CM, Kondo T, Hamad CD, Hu Y, Loftin AH, Johansen DO, Burke Z, Clarkson S, Ishmael C, Hori K, Mamouei Z, Okawa H, Nishimura I, Bernthal NM, Segura T. Point-of-care antimicrobial coating protects orthopaedic implants from bacterial challenge. Nature communications. 2021 Sep;12(1):5473.

Published In

Nature communications

DOI

EISSN

2041-1723

ISSN

2041-1723

Publication Date

September 2021

Volume

12

Issue

1

Start / End Page

5473

Related Subject Headings

  • Treatment Outcome
  • Staphylococcus aureus
  • Staphylococcal Infections
  • Prosthesis-Related Infections
  • Prostheses and Implants
  • Polymers
  • Polyethylene Glycols
  • Point-of-Care Systems
  • Mice, Inbred C57BL
  • Mice