Effects of a novel arginine methyltransferase inhibitor on T-helper cell cytokine production.
Publication
, Journal Article
Bonham, K; Hemmers, S; Lim, Y-H; Hill, DM; Finn, MG; Mowen, KA
Published in: FEBS J
May 2010
The protein arginine methyltransferase (PRMT) family of enzymes catalyzes the transfer of methyl groups from S-adenosylmethionine to the guanidino nitrogen atom of peptidylarginine to form monomethylarginine or dimethylarginine. We created several less polar analogs of the specific PRMT inhibitor arginine methylation inhibitor-1, and one such compound was found to have improved PRMT inhibitory activity over the parent molecule. The newly identified PRMT inhibitor modulated T-helper-cell function and thus may serve as a lead for further inhibitors useful for the treatment of immune-mediated disease.
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Published In
FEBS J
DOI
EISSN
1742-4658
Publication Date
May 2010
Volume
277
Issue
9
Start / End Page
2096 / 2108
Location
England
Related Subject Headings
- T-Lymphocytes, Helper-Inducer
- Structure-Activity Relationship
- Protein-Arginine N-Methyltransferases
- Promoter Regions, Genetic
- Molecular Structure
- Mice, Inbred BALB C
- Mice
- Methylation
- Interleukin-4
- Interferon-gamma
Citation
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Chicago
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Bonham, K., Hemmers, S., Lim, Y.-H., Hill, D. M., Finn, M. G., & Mowen, K. A. (2010). Effects of a novel arginine methyltransferase inhibitor on T-helper cell cytokine production. FEBS J, 277(9), 2096–2108. https://doi.org/10.1111/j.1742-4658.2010.07623.x
Bonham, Kevin, Saskia Hemmers, Yeon-Hee Lim, Dawn M. Hill, M. G. Finn, and Kerri A. Mowen. “Effects of a novel arginine methyltransferase inhibitor on T-helper cell cytokine production.” FEBS J 277, no. 9 (May 2010): 2096–2108. https://doi.org/10.1111/j.1742-4658.2010.07623.x.
Bonham K, Hemmers S, Lim Y-H, Hill DM, Finn MG, Mowen KA. Effects of a novel arginine methyltransferase inhibitor on T-helper cell cytokine production. FEBS J. 2010 May;277(9):2096–108.
Bonham, Kevin, et al. “Effects of a novel arginine methyltransferase inhibitor on T-helper cell cytokine production.” FEBS J, vol. 277, no. 9, May 2010, pp. 2096–108. Pubmed, doi:10.1111/j.1742-4658.2010.07623.x.
Bonham K, Hemmers S, Lim Y-H, Hill DM, Finn MG, Mowen KA. Effects of a novel arginine methyltransferase inhibitor on T-helper cell cytokine production. FEBS J. 2010 May;277(9):2096–2108.
Published In
FEBS J
DOI
EISSN
1742-4658
Publication Date
May 2010
Volume
277
Issue
9
Start / End Page
2096 / 2108
Location
England
Related Subject Headings
- T-Lymphocytes, Helper-Inducer
- Structure-Activity Relationship
- Protein-Arginine N-Methyltransferases
- Promoter Regions, Genetic
- Molecular Structure
- Mice, Inbred BALB C
- Mice
- Methylation
- Interleukin-4
- Interferon-gamma