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Identical twins carry a persistent epigenetic signature of early genome programming.

Publication ,  Journal Article
van Dongen, J; Gordon, SD; McRae, AF; Odintsova, VV; Mbarek, H; Breeze, CE; Sugden, K; Lundgren, S; Castillo-Fernandez, JE; Hannon, E; Min, JL ...
Published in: Nature communications
September 2021

Monozygotic (MZ) twins and higher-order multiples arise when a zygote splits during pre-implantation stages of development. The mechanisms underpinning this event have remained a mystery. Because MZ twinning rarely runs in families, the leading hypothesis is that it occurs at random. Here, we show that MZ twinning is strongly associated with a stable DNA methylation signature in adult somatic tissues. This signature spans regions near telomeres and centromeres, Polycomb-repressed regions and heterochromatin, genes involved in cell-adhesion, WNT signaling, cell fate, and putative human metastable epialleles. Our study also demonstrates a never-anticipated corollary: because identical twins keep a lifelong molecular signature, we can retrospectively diagnose if a person was conceived as monozygotic twin.

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Published In

Nature communications

DOI

EISSN

2041-1723

ISSN

2041-1723

Publication Date

September 2021

Volume

12

Issue

1

Start / End Page

5618

Related Subject Headings

  • Young Adult
  • United Kingdom
  • Twins, Monozygotic
  • Twinning, Monozygotic
  • Retrospective Studies
  • Registries
  • Quantitative Trait Loci
  • Polymorphism, Single Nucleotide
  • Netherlands
  • Middle Aged
 

Citation

APA
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ICMJE
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van Dongen, J., Gordon, S. D., McRae, A. F., Odintsova, V. V., Mbarek, H., Breeze, C. E., … Boomsma, D. I. (2021). Identical twins carry a persistent epigenetic signature of early genome programming. Nature Communications, 12(1), 5618. https://doi.org/10.1038/s41467-021-25583-7
Dongen, Jenny van, Scott D. Gordon, Allan F. McRae, Veronika V. Odintsova, Hamdi Mbarek, Charles E. Breeze, Karen Sugden, et al. “Identical twins carry a persistent epigenetic signature of early genome programming.Nature Communications 12, no. 1 (September 2021): 5618. https://doi.org/10.1038/s41467-021-25583-7.
van Dongen J, Gordon SD, McRae AF, Odintsova VV, Mbarek H, Breeze CE, et al. Identical twins carry a persistent epigenetic signature of early genome programming. Nature communications. 2021 Sep;12(1):5618.
van Dongen, Jenny, et al. “Identical twins carry a persistent epigenetic signature of early genome programming.Nature Communications, vol. 12, no. 1, Sept. 2021, p. 5618. Epmc, doi:10.1038/s41467-021-25583-7.
van Dongen J, Gordon SD, McRae AF, Odintsova VV, Mbarek H, Breeze CE, Sugden K, Lundgren S, Castillo-Fernandez JE, Hannon E, Moffitt TE, Hagenbeek FA, van Beijsterveldt CEM, Jan Hottenga J, Tsai P-C, BIOS Consortium, Genetics of DNA Methylation Consortium, Min JL, Hemani G, Ehli EA, Paul F, Stern CD, Heijmans BT, Slagboom PE, Daxinger L, van der Maarel SM, de Geus EJC, Willemsen G, Montgomery GW, Reversade B, Ollikainen M, Kaprio J, Spector TD, Bell JT, Mill J, Caspi A, Martin NG, Boomsma DI. Identical twins carry a persistent epigenetic signature of early genome programming. Nature communications. 2021 Sep;12(1):5618.

Published In

Nature communications

DOI

EISSN

2041-1723

ISSN

2041-1723

Publication Date

September 2021

Volume

12

Issue

1

Start / End Page

5618

Related Subject Headings

  • Young Adult
  • United Kingdom
  • Twins, Monozygotic
  • Twinning, Monozygotic
  • Retrospective Studies
  • Registries
  • Quantitative Trait Loci
  • Polymorphism, Single Nucleotide
  • Netherlands
  • Middle Aged