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Cell Death: Mechanism and Disease

Programmed necrosis/necroptosis: An inflammatory form of cell death

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Chan, FKM
November 1, 2014

It was not long ago when necrosis was thought to be cell injury caused by nonspecific physical trauma. In recent years, a dedicated pathway that triggers necrosis in response to TNF-like death cytokines, certain toll-like receptors, and in response to viral pathogens was described. Signaling adaptors that contain the RIP homotypic interaction motif (RHIM), such as receptor interacting protein kinase (RIPK) 1 and RIPK3, are key inducers for this form of regulated necrosis, often referred to as programmed necrosis or necroptosis. Genetic and biochemical experiments show that RIP kinase-dependent necrosis and caspase-dependent apoptosis are intimately linked. Unlike apoptosis, necrosis tends to promote inflammation. Emerging evidence indicates that the pro-inflammatory nature of necrosis is a critical driver in a wide range of disease pathologies. In this chapter, I discuss the molecular pathway that controls necrosis and how it contributes to different inflammatory diseases.

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DOI

Publication Date

November 1, 2014

Volume

9781461493020

Start / End Page

211 / 228
 

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Chan, F. K. M. (2014). Programmed necrosis/necroptosis: An inflammatory form of cell death. In Cell Death: Mechanism and Disease (Vol. 9781461493020, pp. 211–228). https://doi.org/10.1007/978-1-4614-9302-0_10
Chan, F. K. M. “Programmed necrosis/necroptosis: An inflammatory form of cell death.” In Cell Death: Mechanism and Disease, 9781461493020:211–28, 2014. https://doi.org/10.1007/978-1-4614-9302-0_10.
Chan FKM. Programmed necrosis/necroptosis: An inflammatory form of cell death. In: Cell Death: Mechanism and Disease. 2014. p. 211–28.
Chan, F. K. M. “Programmed necrosis/necroptosis: An inflammatory form of cell death.” Cell Death: Mechanism and Disease, vol. 9781461493020, 2014, pp. 211–28. Scopus, doi:10.1007/978-1-4614-9302-0_10.
Chan FKM. Programmed necrosis/necroptosis: An inflammatory form of cell death. Cell Death: Mechanism and Disease. 2014. p. 211–228.

DOI

Publication Date

November 1, 2014

Volume

9781461493020

Start / End Page

211 / 228