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Association of subcortical gray-matter volumes with life-course-persistent antisocial behavior in a population-representative longitudinal birth cohort.

Publication ,  Journal Article
Carlisi, CO; Moffitt, TE; Knodt, AR; Harrington, H; Langevin, S; Ireland, D; Melzer, TR; Poulton, R; Ramrakha, S; Caspi, A; Hariri, AR; Viding, E
Published in: Development and psychopathology
October 2021

Neuropsychological evidence supports the developmental taxonomy theory of antisocial behavior, suggesting that abnormal brain development distinguishes life-course-persistent from adolescence-limited antisocial behavior. Recent neuroimaging work confirmed that prospectively-measured life-course-persistent antisocial behavior is associated with differences in cortical brain structure. Whether this extends to subcortical brain structures remains uninvestigated. This study compared subcortical gray-matter volumes between 672 members of the Dunedin Study previously defined as exhibiting life-course-persistent, adolescence-limited or low-level antisocial behavior based on repeated assessments at ages 7-26 years. Gray-matter volumes of 10 subcortical structures were compared across groups. The life-course-persistent group had lower volumes of amygdala, brain stem, cerebellum, hippocampus, pallidum, thalamus, and ventral diencephalon compared to the low-antisocial group. Differences between life-course-persistent and adolescence-limited individuals were comparable in effect size to differences between life-course-persistent and low-antisocial individuals, but were not statistically significant due to less statistical power. Gray-matter volumes in adolescence-limited individuals were near the norm in this population-representative cohort and similar to volumes in low-antisocial individuals. Although this study could not establish causal links between brain volume and antisocial behavior, it constitutes new biological evidence that all people with antisocial behavior are not the same, supporting a need for greater developmental and diagnostic precision in clinical, forensic, and policy-based interventions.

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Published In

Development and psychopathology

DOI

EISSN

1469-2198

ISSN

0954-5794

Publication Date

October 2021

Start / End Page

1 / 11

Related Subject Headings

  • Developmental & Child Psychology
  • 5203 Clinical and health psychology
  • 5202 Biological psychology
  • 5201 Applied and developmental psychology
  • 1702 Cognitive Sciences
  • 1701 Psychology
 

Citation

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ICMJE
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Carlisi, C. O., Moffitt, T. E., Knodt, A. R., Harrington, H., Langevin, S., Ireland, D., … Viding, E. (2021). Association of subcortical gray-matter volumes with life-course-persistent antisocial behavior in a population-representative longitudinal birth cohort. Development and Psychopathology, 1–11. https://doi.org/10.1017/s0954579421000377
Carlisi, Christina O., Terrie E. Moffitt, Annchen R. Knodt, HonaLee Harrington, Stephanie Langevin, David Ireland, Tracy R. Melzer, et al. “Association of subcortical gray-matter volumes with life-course-persistent antisocial behavior in a population-representative longitudinal birth cohort.Development and Psychopathology, October 2021, 1–11. https://doi.org/10.1017/s0954579421000377.
Carlisi CO, Moffitt TE, Knodt AR, Harrington H, Langevin S, Ireland D, et al. Association of subcortical gray-matter volumes with life-course-persistent antisocial behavior in a population-representative longitudinal birth cohort. Development and psychopathology. 2021 Oct;1–11.
Carlisi, Christina O., et al. “Association of subcortical gray-matter volumes with life-course-persistent antisocial behavior in a population-representative longitudinal birth cohort.Development and Psychopathology, Oct. 2021, pp. 1–11. Epmc, doi:10.1017/s0954579421000377.
Carlisi CO, Moffitt TE, Knodt AR, Harrington H, Langevin S, Ireland D, Melzer TR, Poulton R, Ramrakha S, Caspi A, Hariri AR, Viding E. Association of subcortical gray-matter volumes with life-course-persistent antisocial behavior in a population-representative longitudinal birth cohort. Development and psychopathology. 2021 Oct;1–11.
Journal cover image

Published In

Development and psychopathology

DOI

EISSN

1469-2198

ISSN

0954-5794

Publication Date

October 2021

Start / End Page

1 / 11

Related Subject Headings

  • Developmental & Child Psychology
  • 5203 Clinical and health psychology
  • 5202 Biological psychology
  • 5201 Applied and developmental psychology
  • 1702 Cognitive Sciences
  • 1701 Psychology