Skip to main content
Journal cover image

Recruitment and inhibitory action of hippocampal axo-axonic cells during behavior.

Publication ,  Journal Article
Dudok, B; Szoboszlay, M; Paul, A; Klein, PM; Liao, Z; Hwaun, E; Szabo, GG; Geiller, T; Vancura, B; Wang, B-S; McKenzie, S; Homidan, J ...
Published in: Neuron
December 1, 2021

The axon initial segment of hippocampal pyramidal cells is a key subcellular compartment for action potential generation, under GABAergic control by the "chandelier" or axo-axonic cells (AACs). Although AACs are the only cellular source of GABA targeting the initial segment, their in vivo activity patterns and influence over pyramidal cell dynamics are not well understood. We achieved cell-type-specific genetic access to AACs in mice and show that AACs in the hippocampal area CA1 are synchronously activated by episodes of locomotion or whisking during rest. Bidirectional intervention experiments in head-restrained mice performing a random foraging task revealed that AACs inhibit CA1 pyramidal cells, indicating that the effect of GABA on the initial segments in the hippocampus is inhibitory in vivo. Finally, optogenetic inhibition of AACs at specific track locations induced remapping of pyramidal cell place fields. These results demonstrate brain-state-specific dynamics of a critical inhibitory controller of cortical circuits.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Neuron

DOI

EISSN

1097-4199

Publication Date

December 1, 2021

Volume

109

Issue

23

Start / End Page

3838 / 3850.e8

Location

United States

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Synapses
  • Pyramidal Cells
  • Neurology & Neurosurgery
  • Mice
  • Interneurons
  • Hippocampus
  • Axons
  • Animals
  • 5202 Biological psychology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Dudok, B., Szoboszlay, M., Paul, A., Klein, P. M., Liao, Z., Hwaun, E., … Soltesz, I. (2021). Recruitment and inhibitory action of hippocampal axo-axonic cells during behavior. Neuron, 109(23), 3838-3850.e8. https://doi.org/10.1016/j.neuron.2021.09.033
Dudok, Barna, Miklos Szoboszlay, Anirban Paul, Peter M. Klein, Zhenrui Liao, Ernie Hwaun, Gergely G. Szabo, et al. “Recruitment and inhibitory action of hippocampal axo-axonic cells during behavior.Neuron 109, no. 23 (December 1, 2021): 3838-3850.e8. https://doi.org/10.1016/j.neuron.2021.09.033.
Dudok B, Szoboszlay M, Paul A, Klein PM, Liao Z, Hwaun E, et al. Recruitment and inhibitory action of hippocampal axo-axonic cells during behavior. Neuron. 2021 Dec 1;109(23):3838-3850.e8.
Dudok, Barna, et al. “Recruitment and inhibitory action of hippocampal axo-axonic cells during behavior.Neuron, vol. 109, no. 23, Dec. 2021, pp. 3838-3850.e8. Pubmed, doi:10.1016/j.neuron.2021.09.033.
Dudok B, Szoboszlay M, Paul A, Klein PM, Liao Z, Hwaun E, Szabo GG, Geiller T, Vancura B, Wang B-S, McKenzie S, Homidan J, Klaver LMF, English DF, Huang ZJ, Buzsáki G, Losonczy A, Soltesz I. Recruitment and inhibitory action of hippocampal axo-axonic cells during behavior. Neuron. 2021 Dec 1;109(23):3838-3850.e8.
Journal cover image

Published In

Neuron

DOI

EISSN

1097-4199

Publication Date

December 1, 2021

Volume

109

Issue

23

Start / End Page

3838 / 3850.e8

Location

United States

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Synapses
  • Pyramidal Cells
  • Neurology & Neurosurgery
  • Mice
  • Interneurons
  • Hippocampus
  • Axons
  • Animals
  • 5202 Biological psychology