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Can high antimüllerian hormone mitigate some of the age-related decline in live birth rates? The association between antimüllerian hormone and live birth among women over 40 undergoing in vitro fertilization.

Publication ,  Conference
Harris, BS; Acharya, KS; Weber, JM; Truong, T; Eaton, JL
Published in: F S Rep
December 2021

OBJECTIVE: To examine the association between serum antimüllerian hormone (AMH) and live birth among women aged ≥41 years undergoing in vitro fertilization (IVF). DESIGN: Retrospective cohort study using the 2012-2014 Society for Assisted Reproductive Technology Clinic Outcome Reporting System database. SETTING: Fertility clinics reporting to the Society for Assisted Reproductive Technology. PATIENTS: The analysis included 7,819 patients aged ≥41 years who underwent a first fresh, autologous IVF cycle during the study period. Cycles with preimplantation genetic testing were excluded. INTERVENTIONS: None. MAIN OUTCOME MEASURES: Live birth rate. RESULTS: The empirical distribution of AMH was examined, and extreme values were observed. Therefore, the natural logarithm transformation of AMH (log-AMH) was used in all analyses. Before adjustment for covariates, a one-unit increase in log-AMH was associated with doubling of the odds of live birth up to a log-AMH of -0.34 (equivalently, AMH, 0.71 ng/mL; odds ratio [OR], 2.02; 95% confidence interval [CI], 1.66-2.46). Above an AMH level of 0.71 ng/mL, the odds of live birth increased by only 40% with each unit increase in log-AMH (OR, 1.40; 95% CI, 1.22-1.61). After adjusting for covariates, the odds of live birth increased by 91% with each unit increase in log-AMH up to -0.34 (AMH, 0.71 ng/mL; OR, 1.91; 95% CI, 1.56-2.34). Above an AMH level of 0.71 ng/mL, the odds of live birth increased by only 32% with each unit increase in log-AMH (OR, 1.32; 95% CI, 1.15-1.53). CONCLUSIONS: Among women aged ≥41 years undergoing fresh, autologous IVF, the odds of live birth significantly increase with increasing serum AMH level. As the AMH level increases above 0.71 ng/mL, the association maintains statistical significance, but the effect size is diminished.

Duke Scholars

Published In

F S Rep

DOI

EISSN

2666-3341

Publication Date

December 2021

Volume

2

Issue

4

Start / End Page

440 / 447

Location

United States
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Harris, B. S., Acharya, K. S., Weber, J. M., Truong, T., & Eaton, J. L. (2021). Can high antimüllerian hormone mitigate some of the age-related decline in live birth rates? The association between antimüllerian hormone and live birth among women over 40 undergoing in vitro fertilization. In F S Rep (Vol. 2, pp. 440–447). United States. https://doi.org/10.1016/j.xfre.2021.08.009
Harris, Benjamin S., Kelly S. Acharya, Jeremy M. Weber, Tracy Truong, and Jennifer L. Eaton. “Can high antimüllerian hormone mitigate some of the age-related decline in live birth rates? The association between antimüllerian hormone and live birth among women over 40 undergoing in vitro fertilization.” In F S Rep, 2:440–47, 2021. https://doi.org/10.1016/j.xfre.2021.08.009.

Published In

F S Rep

DOI

EISSN

2666-3341

Publication Date

December 2021

Volume

2

Issue

4

Start / End Page

440 / 447

Location

United States