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Bergmann glia and the recognition molecule CHL1 organize GABAergic axons and direct innervation of Purkinje cell dendrites.

Publication ,  Journal Article
Ango, F; Wu, C; Van der Want, JJ; Wu, P; Schachner, M; Huang, ZJ
Published in: PLoS Biol
April 29, 2008

The geometric and subcellular organization of axon arbors distributes and regulates electrical signaling in neurons and networks, but the underlying mechanisms have remained elusive. In rodent cerebellar cortex, stellate interneurons elaborate characteristic axon arbors that selectively innervate Purkinje cell dendrites and likely regulate dendritic integration. We used GFP BAC transgenic reporter mice to examine the cellular processes and molecular mechanisms underlying the development of stellate cell axons and their innervation pattern. We show that stellate axons are organized and guided towards Purkinje cell dendrites by an intermediate scaffold of Bergmann glial (BG) fibers. The L1 family immunoglobulin protein Close Homologue of L1 (CHL1) is localized to apical BG fibers and stellate cells during the development of stellate axon arbors. In the absence of CHL1, stellate axons deviate from BG fibers and show aberrant branching and orientation. Furthermore, synapse formation between aberrant stellate axons and Purkinje dendrites is reduced and cannot be maintained, leading to progressive atrophy of axon terminals. These results establish BG fibers as a guiding scaffold and CHL1 a molecular signal in the organization of stellate axon arbors and in directing their dendritic innervation.

Duke Scholars

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Published In

PLoS Biol

DOI

EISSN

1545-7885

Publication Date

April 29, 2008

Volume

6

Issue

4

Start / End Page

e103

Location

United States

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Synapses
  • Purkinje Cells
  • Neuroglia
  • Microscopy, Electron
  • Mice, Transgenic
  • Mice
  • Developmental Biology
  • Dendrites
  • Cerebellar Cortex
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ango, F., Wu, C., Van der Want, J. J., Wu, P., Schachner, M., & Huang, Z. J. (2008). Bergmann glia and the recognition molecule CHL1 organize GABAergic axons and direct innervation of Purkinje cell dendrites. PLoS Biol, 6(4), e103. https://doi.org/10.1371/journal.pbio.0060103
Ango, Fabrice, Caizhi Wu, Johannes J. Van der Want, Priscilla Wu, Melitta Schachner, and Z Josh Huang. “Bergmann glia and the recognition molecule CHL1 organize GABAergic axons and direct innervation of Purkinje cell dendrites.PLoS Biol 6, no. 4 (April 29, 2008): e103. https://doi.org/10.1371/journal.pbio.0060103.
Ango F, Wu C, Van der Want JJ, Wu P, Schachner M, Huang ZJ. Bergmann glia and the recognition molecule CHL1 organize GABAergic axons and direct innervation of Purkinje cell dendrites. PLoS Biol. 2008 Apr 29;6(4):e103.
Ango, Fabrice, et al. “Bergmann glia and the recognition molecule CHL1 organize GABAergic axons and direct innervation of Purkinje cell dendrites.PLoS Biol, vol. 6, no. 4, Apr. 2008, p. e103. Pubmed, doi:10.1371/journal.pbio.0060103.
Ango F, Wu C, Van der Want JJ, Wu P, Schachner M, Huang ZJ. Bergmann glia and the recognition molecule CHL1 organize GABAergic axons and direct innervation of Purkinje cell dendrites. PLoS Biol. 2008 Apr 29;6(4):e103.
Journal cover image

Published In

PLoS Biol

DOI

EISSN

1545-7885

Publication Date

April 29, 2008

Volume

6

Issue

4

Start / End Page

e103

Location

United States

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Synapses
  • Purkinje Cells
  • Neuroglia
  • Microscopy, Electron
  • Mice, Transgenic
  • Mice
  • Developmental Biology
  • Dendrites
  • Cerebellar Cortex